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EC number: 948-047-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07/05/1997 to 21/05/1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- 92/69/EEC
- Principles of method if other than guideline:
- Short term toxicity test exposing Daphnia magna to the test substance and observing the occurrence of immobilisation of the time frame in order to calculate an EC50.
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Common name of substance: MIGLYOL 8810
CAS number; not specified
Purity: C: 71.08%, H 11.57% 97.9% area % 1,3-butanediol ester
Stability: >1 year
Appearance: clear liquid
Batch number: 704 025
Date of manufacture: 03/04/1997 - Analytical monitoring:
- yes
- Details on sampling:
- Initial testing for determining stability of the test substance:
- Concentrations: 2.4, 1.2 , 0.5 mg/L
- Analysis: carbon content using the TOC analyser
- Sampling times: 24, 48 and 72 hours
- Recovery rate: 80% (samples at some times points are lower and the 0.5mg/L is below detection limit at 24, 48 and 72 hours)
See Table 1 for results - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: a stock was prepared at 1g/L in synthetic freshwater. The stock was stirred for 18 hours and then filtered. The carbon content was then analysed.
- Controls: yes
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): not stated - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain/clone: Staus, clone 5
- Source: Laboratory own breed
- Age of parental stock (mean and range, SD): Not stated
- Feeding during test: No
- Food type: Not applicable
- Amount: Not applicable
- Frequency: Not applicable
CULTURE CONDITIONS
- Culture conditions (same as test or not):M4 medium (1990).
- Type and amount of food: Scenedesmus subspicatus
- Feeding frequency: daily
- Health during acclimation (any mortality observed): not stated - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- not stated
- Test temperature:
- 20 ± 1 ° C
- pH:
- 7.7 to 8.1 at end of test
- Dissolved oxygen:
- not stated
- Salinity:
- not stated
- Conductivity:
- not stated
- Nominal and measured concentrations:
- Nominal - 2mg/L (demonstrated in stability experiment that measured were within 20% of nominal), control
- Details on test conditions:
- Composition of synthetic freshwater: CaCl2 x H2O - 294mg/L, MgSO4 x 7 H2O - 123mg/L, NaHCO3 - 63 mg/L, KCl 5.5 mg/L.
Test set up: roud arch glasses 10ml
Number of test concentrations: 1 exposure + control
Number of replicates: 4
Number of animals in each: 5
Stocking density: 2ml per test organism
Light profile: dark
Aeration: none - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: carbon
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: carbon
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- Immobilisation of Daphnia to the reference substance was assessed at two concentrations, 1 and 2 mg/L. Percentage immobilisation was 40 and 100% respectively. The result were within the normal range and thereof the test can be considered valid
- Validity criteria fulfilled:
- yes
- Remarks:
- Validity criteria relating to reference substance are detailed and fullfilled
- Conclusions:
- The toxicity of the test substance was measured to Daphnia toxicity based on immbolisation. An EC50 of >2.0 mg/L was determined.
- Executive summary:
The toxicity of test substance was assessed in a study conducted according to EC Directive 92/69/EEC and to GLP. Limited information is included in the study report. Daphnia magna were exposed to the test substance for 48 hours at a measured concentration of 2.0mg/L measured based on carbon content. Immobilisation was assessed over this time period. Controls and a reference stubstance were also included.
The 48 hour EC50 was determined at >2.0 mg/L based on immobilisation
Reference
Description of key information
Two studies are presented here for short term toxicity to invertebrates, both using read-across substances. Both studies are reliable (Klimisch 2). The key study was carried out on the read across substance Butylene Glycol Dicaprylate/Dicaprate and resulted in a 48 hour EC50 for Daphnia magna of >2.0 mg/L based on immobilisation. This study has been selected as the key study as it provides the most conservative assessment of toxicity.
The other study was carried out on the read across substance Decanoic acid, mixed diesters with octanoic acid and propylene glycol and resulted in a 48 hour EC50 for Daphnia magna of >2.7mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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