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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 947-962-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP compliant guideline study, available as unpublished report, minor restrictions in design and/or reporting but adequate for assessment.
- Principles of method if other than guideline:
- Test according to the German guideline published in: "Bewertung wassergefahrdender Stoffe"
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- A stock solution containing 25,000 mg/l was prepared in distilled water and sterilized in an autoclave (30 min at 120 °C). Dilutions of the stock solution were prepared
- Test organisms (species):
- Pseudomonas putida
- Details on inoculum:
- A culture of the test organism, the gram negative bacterium Pseudomonas putida was obtained from prof. R. Kuhn. (Institut fur Wasser-, Bodem,- und Lufthygiene des Bundesgesundheitsamtes, Berlin). The bacterium was cultivated according to the method described in "III bestimmung der akuten bakterientoxizitat".
A preculture was prepared, and the test culture was prepared from this preculture by dilution with sterile NaCl- solution (0.5 g/l) until the bacterial suspension had an optical density of 0.43 measured in a 10 mm glass cuvette with a Pye Unicam SP 500 spectrofotometer at 436 nm. - Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 18 h
- Post exposure observation period:
- None
- Hardness:
- No data
- Test temperature:
- 25 °C
- pH:
- No data
- Dissolved oxygen:
- No data
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0; 9.75; 19.5; 39; 78; 156; 312.5; 625; 1250; 2500; 5000; 10000; 20000 mg/l
- Details on test conditions:
- In principle dilutions of the stock solution were prepared, and after addition of bacterial suspension and nutrients, the cultures (in 300 ml conical flasks) were incubated for 18 hours at 25°C
- Reference substance (positive control):
- not specified
- Duration:
- 18 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 20 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Details on results:
- The results show that above 312 mg/l propylene glycol added to the culture there are a slight stimulation of growth, which decreases again above 5000 mg/l. At the highest concentration tested there is a slight inhibition of growth of less than 10%. The toxicity treshold is therefore > 20.000 mg/l.
- Executive summary:
The test was performed according to the German guideline published in: "Bewertung wassergefahrdender Stoffe".
The NOEC of propylene glycol is >20000 mg/L.
Reference
Description of key information
Key value for chemical safety assessment
- EC50 for microorganisms:
- 20 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.