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Diss Factsheets
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EC number: 947-453-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 > 2000 mg/kg b.w
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
ACUTE ORAL TOXICITY
The following data was obtained for Similar Substance 01. It is expected that Target substance will present similar acute oral toxicity. Justification for Read Across is given in Section 13 of IUCLID.
The study was conducted according to the method described into the Directive EC n. 67/548 Annex IV B. B.1 .ter. The substance was administrated by gavage to six rats (3 males and 3 females) at a concentration of 2000 mg/kg bw.
No clinical symptoms were recorded and no deaths occurred. During autopsy no macroscopic changes were seen.
Acute toxicity experimental data obtained using Target Substance is available. Unfortunately, the reliability of the data cannot be judged because of the lacking of details about test material and testing procedures and conditions.
REFERENCE: details in attachment.
The substance was considered as nontoxic with single oral and dermal administration; its intraperitoneal toxicity, however, is slightly higher. Inhalation of an atmosphere saturated with the possibly volatile components of this product at 20 °C is tolerated without symptoms for 8 hours.
Oral and intraperitoneal toxicity
-Observation time: 7 days
-Application form: 3 to 30 % suspension in 0.5 % aqueous carboxymethyl cellulose solution
-Results: approximate - mean lethal dose = LD50 calculated according to LITCHFIELD-WILCOXON
LD50 (rat, oral) 9550 (9026-10104) mg/kg bw
LD50 (mouse, intraperitoneal) about 550 mg
-Symptoms:
Rats oral: Dyspnoea, sometimes slight apathy, diarrheal feces dyed black, tumbling.
Mice intraperitoneal: dyspnea, slight apathy, jumping spasms, spastic gait; skin brownish colored.
-Post mortem examination:
Rats oral: acute cardiac dilatation, congestive hyperemia, stomach dilated, fluid contents, ecchymosed in the glandular stomach, diarrheal intestinal contents, organs stained.
Mice intraperitoneal: intra-abdominal substance precipitation.
Dermal toxicity
-Observation time: 14 days
-Application form: 50 % aqueous preparation
-Results: approximate - mean lethal dose = LD50 calculated according to LITCHFIELD-WILCOXON
LD50 (rat, dermal) > 2500 mg/kg bw.
-Symptoms: no clinical signs observed
-Post mortem examination: no findings
Inhalation Toxicity
Inhalation of a saturated with steam at 20° C resp. dust-enriched atmosphere. To saturation or Enrichment was through an approx. 5 cm high layer of the product passed air.
-Duration of exposure: 8 h
-Test animal: rat
-Mortality (died / exposed animals): 0/12
-Symptoms: no clinical signs observed
-Post mortem examination: no findings
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008) acute toxicity means those adverse effects occurring following oral or dermal administration of a single dose of a substance or a mixture, or multiple doses given within 24 hours, or an inhalation exposure of 4 hours.
The substance is not capable to produce adverse effects after acute administration by oral route, therefore no classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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