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EC number: 811-285-3 | CAS number: 1637294-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 May, 2015 to 01 October, 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- April, 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- NYMPHEAL (GR-88-0778) :
Lot No. : Batch 6
Purity : 98.6% (principal component)
Date of Expiry : 29 March, 2017 - Analytical monitoring:
- yes
- Remarks:
- GC-MS
- Details on sampling:
- A semi-static set-up was employed.
Samples of the 5 exposure levels, C1 to C5, were taken for extraction and analysis, as follows :
- Fresh exposure medium : Time 0 and 24 hours;
- Aged exposure medium : 24 hours and 48 hours.
Samples of the Control and Solvent Control were sampled for analysis at Time 0 (fresh) and 48 hours (aged). - Vehicle:
- yes
- Remarks:
- Stock solutions prepared in Acetone. Maximum loading in exposure media = 0.1 mL/L.
- Details on test solutions:
- Following a Range-Finding study, the Following Nominal test concentrations were chosen for the definitive study :
C1 0.476 mg/L
C2 0.857 mg/L
C3 1.54 mg/L
C4 2.78 mg/L
C5 5.00 mg/L
The exposure solutions were prepared using standards prepared in Acetone as a vehicle. Since NYMPHEAL is a primary aldehyde, and, therefore, susceptible to undergo rapid oxidation, it was decided to avoid long, drawn-out exposure medium preparation techniques (e.g. slow-stirring to obtain water saturated fraction). - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna STRAUS (clone M10), in-house culture.
Holding Conditions :
- Vessel : Glass vessel, 1.8 L
- Medium : Elendt M4
- medium renewal Twice per week
- Temperature : 20 +/- 2°C
- Photoperiod : 16 h light / 8 h dark
- Light Intensity : 50 to 1000 Lux
- Food : Algae (D. subspicatus)
On the day of the test start, neonate daphnids were separated from the parental daphnids which were kept in the selected holding vessels. - Test type:
- semi-static
- Water media type:
- freshwater
- Remarks:
- Medium : Elendt M4
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 254 mg/L CaCO3
- Test temperature:
- 20.4 to 20.9 °C
- pH:
- pH 7.7 to 7.8
- Dissolved oxygen:
- 8.7 to 9.0 mg O2/L
- Conductivity:
- 680 microS/cm
- Nominal and measured concentrations:
- The water samples were simultaneously analysed for the residue of the Parent, and the corre-sponding alcohol (GR-88-1108) and acid (GR-88-1910).
NYMPHEAL was not stable in the exposure solutions over the 24-hour renewal period. The concentrations determined in the Fresh medium samples varied in the range of 79 to 123 % of Nominal, and, 43 - 111% of Nominal in the 24 hour old medium.1
The Time-Weighted Mean Measured concentrations of the Parent over the 96-hour exposure period were, as follows :
Exposure Level Time-Weighted Mean Concn.
Control Not Detected
Solvent Control Not Detected
C1 (0.476 mg/L) 0.298 mg/L
C2 (0.857 mg/L) 0.621 mg/L
C3 (1.54 mg/L) 1.09 mg/L
C4 2.78 mg/L) 2.97 mg/L
C5 (5.00 mg/L) 5.67 mg/L
Amounts of the Acid Metabolite were detected in the 24 hour aged samples (between 10 and 20% of the sapplied dose), and, only one detect of the Alcohol metabolite. Although total equivalent concentrations have been reported in the Final report, the end-points reported hereinare related to Parent, only. - Details on test conditions:
- Age of exposed Daphnids : < 24 hours old
Test duration : 48 hours
Medium : Elendt M4
Biological Parameters : Immobility
Test temperature : 18 - 22 °C
Test vessels : 60 mL glass beakers
Volume of Test Solution : 50 - 60 mL
Number of daphnids per Vessel : 5
Number of replicates per test concentration : 4
Number of Control replicates : 4
Renewal Semi-static (renewal Following 24 hours)
Photoperiod : 16 h light / 8 h dark
Aeration : None - Reference substance (positive control):
- yes
- Remarks:
- Potassium Dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.01 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% Confidence Interval Limits : 0.874 - 1.25 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.621 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Details on results:
- 100% of daphnids were observed to be immobilised in the two highest test concentrations by 48 hours (C4 and C5) and 60% immobilisation at C3 (nominal test concentration of 1.54 mg/L).
- Results with reference substance (positive control):
- The reference test with Potassium Dichromate performed in September 2014 resulted in an EC50 (24 hour) of 1.11 mg/L, which is within the values obtained in the inter-laboratory validation (0.6 to 2.1 mg/L).
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 hour EC50 for Daphnia magna exposed to NYMPHEAL was determined to be 1.01 mg/L.
- Executive summary:
The 48 hour EC50 for Daphnia magna exposed to NYMPHEAL was determined to be 1.01 mg/L
.
Reference
Description of key information
OECD 202 - Acute Daphnia Immobillisation :
EC50 (48 hr) = 1.01 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.01 mg/L
Additional information
OECD 202 - Acute Daphnia Immobillisation :
EC50 (48 hr) = 1.01 mg/L
.
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