Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 810-533-8 | CAS number: 330459-31-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48 h EC50 for Daphnia magna exposed to the test substance under static test conditions was >1.2 mg a.i./L and the NOAEC was 0.42 mg a.i./L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.2 mg/L
Additional information
A study was conducted to assess the toxicity of the test substance to Daphnia magna according to OECD Guideline 202 and US EPA OPPTS 850.1010, in compliance with GLP. Neonatal daphnids were exposed to a geometric series of five nominal test concentrations (0.17, 0.28, 0.47, 0.78 and 1.3 mg a.i./L), a negative control (dilution water) and a solvent control (DMF at 0.1 mL/L) for 48 h under static conditions without aeration. Two replicate test chambers were maintained in each treatment and control group, with 10 daphnids in each test chamber. Observations for immobility and other signs of toxicity were made at approximately 3.5, 24 and 48 h after test initiation. Samples for analytical determinations were collected from the batches of test solutions prepared for the treatment and control groups at the beginning of the test, and from each replicate per treatment and control group at 48 h (± 1 h). The mean measured test concentrations were 0.15, 0.25, 0.42, 0.75 and 1.2 mg a.i./L, representing 88, 91, 89, 96 and 92% of the nominal concentrations respectively. The results of the study were determined based on the mean measured concentrations. Daphnids in the control groups appeared normal throughout the test. Percent immobility in all treatment groups and controls were 0%. After 48 h of exposure, all surviving daphnids in the control groups appeared normal. There were observations of daphnia trapped in the water surface during the first 24 h of the test in both the negative and solvent controls as well as the 0.15, 0.25, 0.42 and 0.75 mg a.i./L treatment groups, but all appeared normal after being submerged beneath the water surface. This was considered incidental to the treatment. There were observations of lethargy at the end of the test in the 0.75 and 1.2 mg a.i./L treatment groups only. Under the test conditions, the 48 h EC50 forDaphnia magnaexposed to the test substance was >1.2 mg a.i./L and the NOAEC was 0.42 mg a.i./L (Thomas ST, 2013).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.