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EC number: 700-954-4 | CAS number: 1338-23-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-09-25 to 1989-12-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- No analysis was performed.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 1984
- Deviations:
- yes
- Remarks:
- No analysis is performed.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1984
- Deviations:
- yes
- Remarks:
- No analysis is performed.
- Principles of method if other than guideline:
- No analysis was performed.
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- The test substance was immiscible with water at the test concentrations and therefore acetone was used as an organic solvent in the preliminary and the definitive test. In the definitive test a stock solution containing 320 g of test substance per acetone was used.
- Test organisms (species):
- Poecilia reticulata
- Details on test organisms:
- TEST ORGANISM
- Common name: Poecilia reticulata (guppy)
- Source: well-known local aquarium retailer
- Length at study initiation: approximately 2 cm - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- hardness of 23°dH
- Test temperature:
- 25 ° and 26 °C
- pH:
- pH (0 h; fresh) = 8.2 - 8.3
pH (96 h; old) = 8.0 - 8.3 - Dissolved oxygen:
- O2 (48 h; old) = 6.4 - 6.8 mg/L
O2 (96 h; old) = 7.1 - 8.3 mg/L - Nominal and measured concentrations:
- nominal concentrations: 10, 18, 32, 56, 100 mg test substance/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: As test vessels were used 2-1 covered glass aquaria which contained 1 L medium. the loading of the test vessels was approximately 0.6 g biomass/L.
TEST MEDIUM / WATER PARAMETERS
The diluting water was a synthetic water, Dutch Standard Water, according to NPR 6507 (1980, having a pH of 8.2 and a hardness of 13°dH. The temperature was kept between 25° and 26°C and light regime was 12 hours of ambient light per day. - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 44.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 36.9 - 53.0 mg/L
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The no observed effect concentration (NOEC) after 96 h amounted to 18 mg/L, whereas 100 mg/L produced 100 % mortality within 24 hours.
No other effects such as deviations in behaviour or appearance of the fish were observed. - Results with reference substance (positive control):
- No positive control
- Reported statistics and error estimates:
- The LC50 was determined with an LC50-programme of Griffioen (RIZA), based on a model of Kooyman (1981).
- Sublethal observations / clinical signs:
Mortality in definitive test:
Number of surviving animals
mg test substance/L
0 h
24 h
48 h
72 h
96 h
Control I
10
10
10
10
10
Control II (acetone)
10
10
10
10
10
10
10
10
10
10
10
18
10
10
10
10
10
32
10
10
10
10
9
56
10
4
3
3
2
100
10
0
-
-
-
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 (96 h) was calculated to be 44.2 mg/L with confidence limits of 36.9 and 53.0 mg/L. The no observed effect concentration (NOEC) after 96 hours amounted to 18 mg/L, whereas 100 mg/L produced 100 % mortality within 24 hours.
- Executive summary:
Methyl-ethylketone peroxide in DMP was tested in an acute toxicity test with Poecilia reticulata (guppy) under semi-statci conditions in accordance with EEC method C.1 (1984) and OECD test Guideline 203 (1985).
Due to the immiscibility of the test substance with water the test concentration were prepared using acetone as a solvent. Each test concentration contained 100 uL acetone/L, as did one control.
The LC50 (96 h) was calculated to be 44.2 mg/L with confidence limits of 36.9 and 53.0 mg/L. The no observed effect concentration (NOEC) after 96 hours was 18 mg/L, whereas 100 mg/L produced 100 % mortality within 24 hours.
No other effects, such as deviation in the behaviour or appearance of fish were observed.
Reference
Description of key information
Methyl-ethylketone peroxide in DMP was tested for acute toxicity to fish to EU-method C.1 (1984) and OECD guideline 203 (1984). In this 96-hour semi-static toxicity test with Poecilia reticulata (guppy), the LC50 value was 44.2 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 44.2 mg/L
Additional information
Methyl-ethylketone peroxide in DMP was tested for acute toxicity to fish to EU-method C.1 (1984) and OECD guideline 203 (1984). In this 96-hour semi-static toxicity test with Poecilia reticulata (guppy), the LC50 value was 44.2 mg/L. The no observed effect concentration (NOEC) after 96 hours was 18 mg/L, whereas 100 mg/L produced 100 % mortality.
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