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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 930-964-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
Reaction mass of methyl chloroacetate and chloroacetic acid:
1.- Monochloroacetic acid:
The only information available on the sensitizing properties of this substance is a short description of a sensitization study. However, due to the limited reporting, this study is not considered reliable for the evaluation of the sensitizing potential of the substance.
According to column 2 of REACH Annex VII, a sensitisation study does not need to be conducted since the substance is classified as corrosive to the skin.
2.- Methyl chloroacetate:
Based on the QSAR estimation using the OECD Toolbox v1.1, the substance is considered to be a skin sensitiser. Furthermore, as published in an article, the analogue monochloro acetic acid ethyl ester (EMCA) was tested in the Guinea Pig Maximization Test (Magnusson and Kligman) to determine its possible sensitizing potential. EMCA showed the capacity to sensitize 5 of 20 guinea pigs. On day 49, cross-reaction patterns to the methyl ester of MCA (MMCA) were studied in four animals. All animals reacted to MMCA (5%-0.5%). EMCA is concluded to be a sensitizer to humans. Cross reactivity to MMCA may occur. According to the CLP Regulation, the substance is classified as Skin Sensitizer Category 1.
Migrated from Short description of key information:
Skin sensitisation: Reaction mass of methyl chloroacetate and chloroacetic acid: Data waiving: According to column 2 of REACH Annex VII, the study does not need to be conducted since the substance is classified as corrosive to the skin.
Monochloroacetic acid: the only information available on the sensitizing properties of this substance is a short description of a sensitization study. However, due to the limited reporting, this study is not considered reliable for the evaluation of the sensitizing potential of the substance.
Methyl chloroacetate: Weight of evidence: Read across from results published in an article with the analogue monochloro acetic acid ethyl ester and QSAR estimation using the OECD Toolbox.
Justification for classification or non-classification
Monochloroacetic acid:
No data for the evaluation of the sensitizing potential of the substance.
According to column 2 of REACH Annex VII, a sensitisation study does not need to be conducted since the substance is classified as corrosive to the skin.
Methyl chloroacetate:
Skin Sensitizer Category 1.
Conclusions:
Based on the skin sensitisation data for the substances mentioned above and their concentrations, the following classification is proposed following the classification criteria for mixtures included in the CLP Regulation:
Skin sensitizer Category 1 (since methyl chloroacetate is present in a concentration of more than 1%).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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