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EC number: 434-280-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- other: Weight of evidence
- Adequacy of study:
- supporting study
- Justification for type of information:
- See attached weight of evidence for complete assessment.
EC 434-280-4 is a salt of an alkyl amine and one of the following three acids: an alkyl dithiodiphosphoric acid (78-64-8); mono butyl phosphate (CAS 1623-15-0); or dibutyl phosphate (DBP, CAS 107-66-4). DBP is classified as a carcinogen (category 2) and, therefore, the purpose of this assessment is to determine whether EC 434-280-4 warrants classification as a carcinogen due to the presence of DBP in the final salt reaction product. There is no residual DBP present after the reaction. In addition, the potential risk of cancer from DBP is addressed.
Based on the weight of evidence, EC 434-280-4 does not warrant classification as a carcinogen and the risk of carcinogenicity from EC 434-280-4 exposure is low.
Following are the key pieces of evidence considered to reach these conclusions:
1. DBP is classified as carcinogen based on read across from a similar material, tri-butyl phosphate (TBP, 126-73-8).
a. TBP is not a genotoxic carcinogen. The mode of carcinogenic action is by causing cellular damage in the bladder, which leads to cell proliferation and then, potentially, bladder cancer.
i. Therefore, for cancer to occur, a dose that causes urinary cell damage over extended exposure periods are required. This is based on mechanistic studies that showed the effect is reversible (does not transition to carcinoma) if exposure is stopped.
b. DBP was also negative in genotoxicity testing.
c. In a Combined Repeat Dose Toxicity Study with the Reproductive/Developmental Toxicity Screening Test (OECD 422), DBP did result in urinary bladder cell proliferation (epithelial hyperplasia), demonstrating read across from TBP is likely appropriate
2. EC 434-280-4 has a 28-day repeated dose toxicity study (OECD 407) of similar treatment length and dose (NOAEL = 30 mg/kg bw/day) to the DBP study that showed no effects on the urinary bladder
a. This is supportive evidence that the DBP associated with EC 434-280-4 is unlikely to cause urinary bladder cancer
b. It should be noted that the highest dose (300 mg/kg bw/day) was terminated after 11 days due to severe toxicity (lethality and moribundity)
3. EC 434-280-4 is currently classified as causing target organ toxicity (category 2) based on the severe toxicity that occurred, which is attributed to the alkyl amine functionality
4. Upon ingestion, it is expected that the EC 434-280-4 salt will dissociate to the starting materials, including DBP
a. The concentration of DBP required to cause bladder cell damage if EC 434-280-4 were to be ingested is unlikely to occur because other effects, characterized as severe toxicity (lethality, moribundity,) as well as immunotoxicity, will occur from EC 434-280-4 well before doses of DBP are reached that will cause bladder effects
5. EC 434-280-4 salt is stable under normal handling conditions in lubricating base oil
Data source
Materials and methods
Test material
- Reference substance name:
- Octadec-9-en-1-yl ammonium mono and di-butylphosphate
- Molecular formula:
- C22H48NO4P - C26H56NO4P
- IUPAC Name:
- Octadec-9-en-1-yl ammonium mono and di-butylphosphate
- Reference substance name:
- Octadec-9-en-1-yl ammonium di-n-hexyl phosphorodithioate
- Molecular formula:
- C30H64NO2PS2
- IUPAC Name:
- Octadec-9-en-1-yl ammonium di-n-hexyl phosphorodithioate
- Test material form:
- liquid: viscous
- Details on test material:
- Material is a yellow viscous liquid
Constituent 1
Constituent 2
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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