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EC number: 298-715-8 | CAS number: 93821-29-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 05, 2018 - September 08, 2018
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Remarks:
- Detection of test item in n-Hexane and n-octanol using both GC-MSD and HPLC-PDA methods.
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Chemical Name Amines, N-tallow alkyl trimethylenedi-reaction products with epichlorohydrin
CAS Number 93821-29-5
Batch Number ST-637
Molecular weight Not available
Molecular Formula Not available
Purity % 100 %
Manufacturing date March 2018
Expiry date February 2019 - Analytical method:
- gas chromatography
- high-performance liquid chromatography
- mass spectrometry
- photometric method
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 2
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other:
- Remarks:
- it was impossible to define the partition coefficient value in a precise and accurate way. However considering the lipophilic nature of the test item and its poor solubility (~10-2 g/L, or lesser than, referred from RCC study No., 8036), the log Pow would be > 2.
- Details on results:
- The partition coefficient of test item, poly flow 130 cannot be precisely and accurately defined. The following hypothesis supports the conclusion phase.
The solubility of test item depends on its purity; any presence of impurities will enhance or decree the solubility of test item in water and n-octanol. This has been substantiated for the test item Poly flow 130 by multiple peaks resolved in HPLC and GC technique. Moreover the different fragmentation pattern for different peaks resolved augments the hypothesis of purity cannot be well defined.
In case the test item was of highly reactive / unstable in original form / catalyst, it needs to be stabilized using certain solvents / inert chemicals / stabilizing oils / buffers to preserve its originality for industrial purpose, thereby preventing refining of analytical reference standard. In such situation also multiple peaks resolve based on instrument conditions thereby supporting the hypothesis of test item identity under normal environment may behave differently and its partitioning property between two immiscible solvents cannot be well precisely and accurately defined.
However the poor solubility of test item (as a whole) in water and greater solubility in n-octanol augments that the test item is lipophilic thereby favoring the log Pow value greater than 4.0. - Conclusions:
- The Partition coefficient of the liquid test item was log Pow > 2.
- Executive summary:
The objective of this study was to determine the partition coefficient (log Pow) for Polyflo130 following EC Guideline A.24 and OECD 107 /OECD117 guidelines. Since the test item is an UVCB and poorly soluble in water (< 10-2g/L), the partition coefficient value was impossible to measure in a precise and accurate way.
The test item was found to be highly soluble in n-Octanol, while in water it forms dispersion and coagulation. The poor solubility of test item (as a whole) in water and greater solubility in n-octanol augments that the test item is lipophilic.
The results from chromatogram / spectrum of respective instrumentation technique revealed that both the instrumentation techniques resolved the test item in to multiple peaks. The different fragmentation pattern and different absorbance pattern obtained from GC-MS and HPLC – PDA spectrum substantiates that the test item consists of several homologous component. Non-availability of the analytical reference standard, molecular weight and molecular formula made identification of peaks cannot be done.
Hence considering the above facts it was impossible to define the partition coefficient value in a precise and accurate way. However considering the lipophilic nature of the test item and its poor solubility (~10-2 g/L, or lesser than, referred from RCC study No., 8036), the log Pow would be > 2.
Reference
Description of key information
PolyFlo130 (OECD 107): the log Pow > 2
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2
- at the temperature of:
- 20 °C
Additional information
The objective of this study was to determine the partition coefficient (log Pow) for Polyflo130 following EC Guideline A.24 and OECD 107 /OECD117 guidelines. Since the test item is an UVCB and poorly soluble in water (<10-2g/L), the partition coefficient value was impossible to measure in a precise and accurate way.
The test item was found to be highly soluble in n-Octanol, while in water it forms dispersion and coagulation. The poor solubility of test item (as a whole) in water and greater solubility in n-octanol augments that the test item is lipophilic.
The results from chromatogram / spectrum of respective instrumentation technique revealed that both the instrumentation techniques resolved the test item in to multiple peaks. The different fragmentation pattern and different absorbance pattern obtained from GC-MS and HPLC – PDA spectrum substantiates that the test item consists of several homologous component. Non-availability of the analytical reference standard, molecular weight and molecular formula made identification of peaks cannot be done.
Hence considering the above facts it was impossible to define the partition coefficient value in a precise and accurate way. However considering the lipophilic nature of the test item and its poor solubility (~10-2 g/L, or lesser than, referred from RCC study No., 8036), the log Pow would be > 2.
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