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EC number: 277-288-1 | CAS number: 73138-39-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- Toxicity control of ready biodegradability test according to OECD 301F
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 Oct - 12 Dec 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data based on the inhibition control of a ready biodegradability study. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2017).
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: Toxicity control of OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1992
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Details on sampling:
- SAMPLING
- Sampling frequency: on days 0, 1, 2, 3, 4, 6, 9, 13, 20, 28
- Sampling method: Oxygen consumption was measured by decreasing of the pressure in the bottles. The Biological Oxygen Demand values were extracted from the measurement heads. - Vehicle:
- no
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- - Source of inoculum/activated sludge: Valence’s Waste treatment Plant (collected on 26th October 2017)
- Pretreatment: The sludge was settled and the liquid supernatant discarded. The concentrated sludge was then suspended in the mineral solution. These two steps were repeated twice.
- Concentration of sludge: The concentration of suspended solids was determined after rinsing the sludge. An activated sludge volume was filtered on a 1.2 μm filter with a vacuum pump. Then, the filter
was dried in drying oven at 105 °C. Solid matter was 4.52 g/L. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 20.5 ° C ± 1
- pH:
- 7.5 - 7.8 (at Day 0 and 28)
- Nominal and measured concentrations:
- Nominal: 23.1 mg test item/L
- Details on test conditions:
- TEST CONDITIONS
- Composition of medium: according to the OECD 301F guideline
- Additional substrate: no
- Solubilising agent (type and concentration if used): no
- Continuous darkness: yes
- Other: The flasks were closed with the measuring heads and stirred with a magnetic stirrer.
TEST SYSTEM
- Culturing apparatus: 650 mLwhite glass bottles
- Number of culture flasks/concentration: 1
- Measuring equipment: heads and oxitop® controller
- Details of trap for CO2: The CO2 released was trapped by soda pellets.
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 replicates (250 mL tes media + 1.7 mL inoculum)
- Reference control: 2 replicates (250 mL test media + 26.3 mL reference item + 1.7 mL inoculum)
- Abiotic control: 1 replica (23.2 mL test item + 250 mL media) - Reference substance (positive control):
- yes
- Remarks:
- benzoic acid, sodium salt
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 23.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: O2 consumption
- Remarks on result:
- other: Result of toxicity control from ready biodegradability test
- Details on results:
- 70.4 % biodegradation took place in the toxicity control within 13 d and therefore the test item was not toxic to micro-organisms.
The degradation of test item was not abiotic as the abiotic control revealed. - Results with reference substance (positive control):
- > 60% biodegradation of the reference substance took place within 13 d (84.9 and 83.8%).
- Validity criteria fulfilled:
- not applicable
Reference
BIOLOGICAL RESULTS:
Table 1: % Biodegradation of reference control, toxicity control and abiotic control
Time (Days) | Reference control A | Reference control B | Test item solution A | Test item solution B | Toxicity control | Abiotic control |
0 | 0 | 0 | 0 | 0 | 0 | 0 |
0.5 | 0 | 0 | 0.7 | 1.5 | 0.5 | 5.3 |
1 | 10.5 | 9.8 | 7.4 | 8.5 | 7.6 | 4.5 |
2 | 36.4 | 38 | 14.1 | 14.7 | 12.9 | 3.8 |
3 | 48.1 | 47.8 | 18 | 19.5 | 16.4 | 4.5 |
4 | 61.8 | 60.9 | 22.6 | 23.6 | 21.3 | 4.1 |
6 | 76.2 | 73.5 | 27.5 | 29.4 | 45.4 | 4.5 |
9 | 81.4 | 80.8 | 34.5 | 35.9 | 52.6 | 4.5 |
13 | 84.9 | 83.8 | 41.1 | 42.1 | 57.7 | 4.1 |
20 | 89 | 91.7 | 52.5 | 54 | 72.4 | 3.7 |
28 | 90.2 | 92.9 | 59.2 | 60.9 | 82.5 | 4.1 |
Description of key information
NOEC (14 d) >= 23.1 mg/L (nominal, toxicity control, OECD 301F, activated sludge)
Key value for chemical safety assessment
Additional information
Since no studies on the toxicity to aquatic microorganisms are available the results of a ready biodegradability study are used to draw conclusion on the toxicity of the substance to aquatic microorganisms. If a compound biodegrades readily in a biodegradability test or does not inhibit at a certain concentration the degradation of a reference substance in the positive control the substance is not considered toxic to microorganisms and the concentration applied in the toxicity control can be set as the NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2017).
A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on ThOD occurred within 14 days (OECD guideline 301).
For the test item fatty acids, coco, esters with 1,3-butanediol (CAS 73138-39-3) a biodegradation test according to OECD guideline 301F is available. The test includes a toxicity control, which contains 23.1 mg/L of the test item and 24.4 mg/L benzoic acid. The toxicity control attained 57.7% degradation after 13 days of incubation. Hence, the substance is considered not toxic to aquatic microorganisms and the test item concentration of 23.1 mg/L can be used as NOEC.
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