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EC number: 272-574-2 | CAS number: 68890-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 2.6 µg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 18 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.26 µg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 5.83 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 5 mg/kg sediment dw
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.5 mg/kg sediment dw
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 10.4 mg/kg soil dw
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 3.3 mg/kg food
- Assessment factor:
- 300
Additional information
Based on the available data for the aquatic compartment, Octopirox is most toxic to daphnia with an acute EC50 (48h) river water of 1.8 mg/L and a chronic NOEC reproduction (21d) river water of 0.13 mg/L.
Based on the available data for the freshwater sediment compartment Octopirox is equally toxic to the endobenthic worm Lumbriculus variegatus and the nematode Caenorhabditis elegans both with an NOEC reproduction (28d) of 250 mg/kg dw.
Based on the available data for the terrestrial compartment Octopirox is most toxic to soil microorganisms with an EC10 of 104 mg/L soil dw.
Conclusion on classification
Short-term effects
The Environmental classification with respect to short-term effects has to take into account the lowest acute value for aquatic species which is the Daphnia EC50 (48h) of 1.8 mg/L (see Section 6.1.5). This study was carried out in river water because a test in reconstituted water is technically not feasible as Octopirox reduces the nutrient ions. This means that the classification has to be based on the river water results.
In addition Octopirox is not readily biodegradable but is rapidly degraded by direct photolysis in water (DT50 0.9d, complete desintegration of the pyridine ring). In addition Octopirox an octanol water partitioning coefficient of 3.86 was measured (see Section 4.7) and therefore bioaccumulation is not expected. Although the bioconcentration criteria of DSD 67/548/EECis formally fulfilled (Log Kow >=3) it is scientifically not justified to assign a R53 especially as the more modern bioconcentration criteria of CLP2011/286/EU(log Kow >= 4) is not fulfilled and the substance Octopirox is rapidly photolyzed in water. From a scientific point of view it makes not much sense to classify Octopirox according 67/548/EEC as a substance with long-term effects (R51/53) and under CLP2011/286/EU assign no classification. This would also confuse the down-stream user of Octopirox.
Based on these facts an environmental classification should be based on the ecotoxicity only as the criteria for long-term effects are not fulfilled.
Proposed classification according DSD 67/548/EEC for Short-term effects:
formally R51/53, from a scientific point of view: NO CLASSIFICATION
Proposed classification according CLP2011/286/EU for Short-term effects:
NO CLASSIFICATION
Long-term (chronic) effects
According to the 2ndATP of CLP (286/2011/EU) there are different approaches for the environmental classification of Long-term effects depending on the number of available chronic ecotoxicity data. As two chronic ecotoxicity data for Octopirox are available two approaches have to be checked: a) the approach based on acute data only and b) the approach using the chronic ecotoxicity data. The more stringent result has to be used for the Environmental classification of Long-term effects. In this case the classification on the chronic data is based on the NOEC Daphnia( 21d) 0.13 mg/L (see Chapter 7.1.1.2.2) which leads for substances which are rapidly degraded to Chronic Category 3 Classification. In Summary
Proposed classification according DSD 67/548/EEC for Long-term effects:
formally R51/53, from a scientific point of view: NO CLASSIFICATION
Proposed classification according CLP2011/286/EU for Long-term effects:
Chronic Category 3, H412
OVERALL ENIVIRONMENTAL CLASSIFICATION
Proposed classification according DSD 67/548/EEC for Short-term & Long-term effects:
formally R51/53, from a scientific point of view: NO CLASSIFICATION
Proposed classification according CLP2011/286/EU for Short-term & Long-term effects:
Chronic Category 3, H412
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