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EC number: 268-159-0 | CAS number: 68015-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 18, 2016 - June 7, 2016
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- other: Water-Accomodated Fraction Methods
- Key result
- Water solubility:
- < 1.39 mg/L
- Temp.:
- 22 °C
- pH:
- ca. 8.01
- Details on results:
- Mean measured test substance concentrations in samples processed from the treated test vessel stirred and equilibrated at 22°C for 24, 48, and 72 hours were all less than the LOQ (1.39 mg/L). With replicate determinations at
The pH of the dilution water used to prepare the test system vessels was 8.01 at 22°C. The measured pH of an aliquot from the treated test vessel stirred and equilibrated at 22°C for 24, 48, and 72 hours was 8.32, 8.28, and 8.28 respectively. The measured pH of an aliquot from negative control stirred and equilibrated at 22°C for 24, 48, and 72 hours was 8.28, 8.31, and 8.32 respectively. - Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of EXP1505385 in well water at 22 ºC was determined using the slow stir method. Solubility samples were collected, filtered, acidified and analyzed for TOC content. The mean water solubility (n = 8) was determined to be <1.39 mg/L. - Executive summary:
The study was performed based in part on procedures in the U.S. EPA Product Properties Test Guidelines,OPPTS 830.7840,Water Solubility: Column Elution Method; Shake Flask Method and OECD Guideline for the Testing of Chemicals, 105: Water Solubility. The experimental portion of the definitive study was conducted between April 18, 2016 and April 22, 2016.
The water solubility of EXP1505385 in well water at 22 ºC was determined using the slow stir method. Solubility samples were collected, filtered, acidified and analyzed for TOC content. The mean water solubility (n = 8) was determined to be
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 February 2000 - 16 February 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- The neat test substance was stored at room temperature.
- Key result
- Water solubility:
- ca. 0 g/L
- Conc. based on:
- test mat. (total fraction)
- Temp.:
- 20 °C
- pH:
- > 4.5 - < 5.8
- Details on results:
- Results of the two water solubility micro-column runs are listed in Table 1. In the first run with a column flow of 0.51 mL/min, the water solubility is calculated from fractions five through nine, which yield a mean of 0.0462 µg/mL with a standard deviation of 0.0103 µg/mL and RSD of 22.3%. In the second run with a flow of 0.26 mL/min, fractions two through six appear to be at the saturation plateau and result in a mean of 0.0324 µg/mL, standard deviation of 0.0034 µg/mL and RSD of 10.5%. The overall mean water solubility reported is 0.0393 µg/mL (4 x 10-5 g/L). Though the means differ by only 0.0138 µg/mL, this corresponds to a difference of just under 30% due to the very low absolute concentrations measured.
- Conclusions:
- The measured water solubility of the Substance was determined to be 0.04 mg/L (4 x 10-5 g/L) at 20°C.
- Executive summary:
The water solubility of the Substance was determined using the procedures outlined in the Organization for Economic Cooperation and Development Guideline for testing of Chemicals 105, "Water Solubility, Column Elution Method" and European Economic Community Annex V, A.6 "Water Solubility". The water solubility of a substance is a critical parameter required for hazard assessment.
The measured water solubility of the Substance was determined to be 0.04 mg/L (4 x 10 -5 g/L) at 20°C.
Referenceopen allclose all
Water Solubility of EXP1505385 at 22°C
Sample Number (523C-210,222-) |
Sampling Interval (hrs) |
Concentrations of the Test Substance |
|
||||
Nominal (mg/mL) |
Measured5 (mg C/L) |
Background1,5,6 Corrected Result (mg C/L) |
Analytical2,5,6Result (mg/L) |
Mean Analytical Result4 (mg/L) |
%3Difference |
||
V3-24-1 |
24 |
0.0500 |
(0.8953) |
(0.159) |
(0.221) |
<LOQ |
|
V3-24-2 |
24 |
0.0500 |
(0.8714) |
(0.135) |
(0.188) |
N/A |
|
V3-24-3 |
24 |
0.0500 |
(0.8187) |
(0.0825) |
(0.115) |
|
|
V3-48-1 |
48 |
0.0500 |
(0.9579) |
(0.222) |
(0.308) |
<LOQ |
|
V3-48-2 |
48 |
0.0500 |
1.044 |
(0.308) |
(0.428) |
N/A |
|
V3-48-3 |
48 |
0.0500 |
(0.6544) |
(-0.0818) |
(-0.114) |
|
|
V3-72-2 |
72 |
0.0500 |
(0.8469) |
(0.111) |
(0.154) |
<LOQ |
N/A |
V3-72-3 |
72 |
0.0500 |
(0.8509) |
(0.115) |
(0.159) |
||
Overall Mean (24, 48, and 72 hrs) Standard Deviation CV |
<LOQ N/A N/A |
|
|
||||
1Background Corrected Result (mg C/L) = Measured Result (mg C/L) – Overall Mean of the Negative Control samples (0.736 mg C/L). 2Analytical Result (mg/L) = Background Corrected Result (mg C/L) / %C in Test Substance (71.9%) x 100. 3 % Difference is calculated as absolute value of the difference between two mean results for two consecutive sampling intervals divided by the mean of the results for the two intervals. Because the analytical results were less than LOQ, the percent difference could not be calculated. 4The method limit of quantitation (LOQ) for EXP1505385 in well water was 1.39 mg/L, calculated as the concentration of the lowest level calibration standard (1.00 mg C/L) divided by the wt %C in the test substance (71.9%). 5Results in parentheses are extrapolated values, below the LOQ for the analytical method. 6Results were generated using Microsoft®Excel 2010 in full precision mode. Manual calculations may differ. |
See attached background documents
Description of key information
Two studies were performed on the registered substance. The water solubility is considered to be was determined to be 0.04 mg/L (4 x 10-5g/L) at 20°C
Key value for chemical safety assessment
- Water solubility:
- 0.04 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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