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Diss Factsheets
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EC number: 267-499-7 | CAS number: 67874-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No skin sensitisation study with bismuth tris (2-ethylhexanoate) is available, thus the skin sensitisation potential will be addressed with existing data on the individual moieties bismuth and 2-ethylhexanoate.
Bismuth tris (2-ethylhexanoate) is not expected to show signs of dermal sensitisation, since the two moieties bismuth and 2-ethylhexanoate have not shown any skin sensitisation potential in experimental testing.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Bismuth
In an available guideline study with the more bioavailable substance, bismuth hydroxide nitrate oxide, the sensitising potential was determined in the LLNA in mice. Three concentrations (10%, 25% and 50%) of the test item, a positive and a vehicle control were tested. Results show that bismuth hydroxide nitrate oxide does not reveal any sensitising properties. Therefore, it can be considered that bismuth metal has no sensitising properties and should not be classified as such.
2-ethylhexanoic acid
In a guinea pig maximization assay (Berol Kemi AB, 1979), 0/10 female Dunkin-Hartley guinea pigs exhibited a response 48 h after induction and challenge with 5 % (w/w) and 2 % (w/w) aqueous 2‑ethylhexanoic acid solution, respectively. The intracutaneous injections were performed with 1 % (w/w) aqueous 2-ethylhexanoic acid solution. In summary, there is no evidence of a notable sensitization potential of 2-ethylhexanoic acid.
Bismuth tris (2-ethylhexanoate)
Bismuth tris (2-ethylhexanoate) is not expected to show signs of dermal sensitisation, since the two moieties bismuth and 2-ethylhexanoate have not shown any skin sensitisation potential in experimental testing. Thus, bismuth tris (2-ethylhexanoate) is not to be classified according to regulation (EC) 1272/2008 as skin sensitising. Further testing is not required. For further information on the toxicity of the individual assessment entities, please refer to the relevant sections in the IUCLID and CSR.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Bismuth tris (2-ethylhexanoate) is not expected to show signs of dermal sensitisation, since the two moieties bismuth and 2-ethylhexanoate have not shown any skin sensitisation potential in experimental testing. Thus, bismuth tris (2-ethylhexanoate) is not to be classified according to regulation (EC) 1272/2008 as skin sensitising.
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