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EC number: 254-751-6 | CAS number: 40018-26-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-09-30 to 2003-12-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- OECD, 1992
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,4-dithiane-2,5-diol
- EC Number:
- 254-751-6
- EC Name:
- 1,4-dithiane-2,5-diol
- Cas Number:
- 40018-26-6
- Molecular formula:
- C4H8O2S2
- IUPAC Name:
- 1,4-dithiane-2,5-diol
- Test material form:
- other: crystalline powder
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: between 2 and 4°C
- Solubility and stability of the test substance in the solvent/vehicle: The water solubillty of 1,4-Dithiane-2,5-diol was given as 3.9 g/L.
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: Preliminary solubility testing indicated that a concentrated stock solution of the test item could not be prepared. Therefore, a dilute test item solution, with a ThOD of 4.23 mg/L, was prepared by adding 20,12 mg of the test item to 2-L of inoculated nutrient dilution water.
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Supernatant from settled domestic activated sludge, Source: Galt Wastewater Treatment Plant, Cambridge, Ontario, Canada; Date Collected: 2003-11-11; Date Used: 2003-1 1-1 I
- Inoculum concentration: Approximately 1.0 mL/L - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2.52 mg/L
- Based on:
- test mat.
- Remarks:
- Based on molecular structure, the calculated ThOD was 1.68 mg ThOD / mg test item
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral medium, pH 7.2
- Additional substrate: reference substrate for inhibition testing: phthalic acid
- Solubilising agent (type and concentration if used): Dilution water: Deionized water with nutrients
- Test temperature: 22 +/- 2 °C
- pH: 7.4 +/- 0.2
- pH adjusted: no
- Continuous darkness: yes
- Other: a dilute test item solution, with a ThOD of 4.23 mg/L, was prepared by adding 20,12 mg of the test item to 2-L of inoculated nutrient dilution water. Based
on visual observations made after three hours and ten minutes of stirring the test item solution, some small dust-like particles remained undissolved in the solution. This
test item solution was divided between the BOD bottles for the Test Series and the Inhibition Series.
TEST SYSTEM
- Culturing apparatus: Non-renewal, closed bottle; Glass, with ground glass stoppers and plastic
seals; Test volume: 300 ml
- Number of culture flasks/concentration: 2 replicates
- Measuring equipment: Oxygen electrode
SAMPLING
- Sampling frequency: 7 day interval
CONTROL AND BLANK SYSTEM
- Toxicity control: reference substrate for inhibition testing: phthalic acid; Reference Concentration: 2.76 mg/L; ThOD Reference Substance: 1.44 mg ThOD/mg reference substance
Reference substance
- Reference substance:
- other: Phthalic Acid, ACS, 99.5+% (Assay)
- Remarks:
- CAS # 88-99-3, Lot Number: C14K39, Chemical Name/ Synonym: 1,2-Benzenedicarboxylic acid; o-dicarboxybenzene Chemical Formula: C6H4(COOH)2
Results and discussion
- Test performance:
- A reference substance testing was conducted in parallel with the definitive test to demonstrate consistency in laboratory test performance that might be affected by such factors as inoculum quality and performance of technical staff. The reference substance used in this study was phthalic acid.
REFERENCE TEST: The reference substance test passed the criteria for acceptability of the results (i.e., >60% degradation in 14 days).
INIHIBITION TEST: Inhibition not observed (i.e., >25% degradation)
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 0 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 4.7
- Sampling time:
- 7 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 40.2
- Sampling time:
- 14 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 55.5
- Sampling time:
- 21 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 47.2
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- REFERENCE TEST: The reference substance test passed the criteria for acceptability of the results (i.e., >60% degradation in 14 days).
INIHIBITION TEST: Inhibition not observed (i.e., >25% degradation)
Any other information on results incl. tables
REFERENCE SUBSTANCE AND INHIBITION DATA
Reference: Phthalic Acid
Day | 0 | 7 |
14 | 21 | 28 |
Reference, % degradation at time = x |
0.0 |
75.5 |
78.0 |
84.3 |
83 |
Inhibition, % degradation at time = x |
0.0 |
>25 |
>25 |
>25 |
>25 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- A test according to OECD 301D showed the test substance being not readily biodegradable (47.2% degradation after 28 days). The test substance was not inhibitory for the degradation (>25%) of the reference substance at 2.52 mg/L).
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