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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 250-801-6 | CAS number: 31778-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- This selected scenario covers the category approach for which the read-across hypothesis is based on structural similarity. For the REACH information requirement under consideration, the property investigated in studies conducted with different source substances is used to predict the property that would be observed in a study with the target substance if it were to be conducted. Similar properties are observed for the different source substances; this may include absence of effects for every member of the category.
There are expected to be differences in strength of the effects forming a regular pattern. The prediction will be based on a worst-case approach or trend analysis as appropriate for the respective endpoint. The read-across is a category approach based on the hypothesis that the substances in this category share structural similarities with common functional groups. This approach serves to use existing data on aquatic toxicity for substances in this category.
The hypothesis corresponds to Scenario 4 of the RAAF. The substances MMP, BuMP, EHMP, iOMP, iC13MP, ODMP, GDMP, TMPMP, PETMP, and Di-PETMP are esters of a common acid, 3-mercaptopropionic acid (3-MPA). The key functionality and main driver for ecotoxicity of the substances within this category is the presence of free SH-groups. It can be predicted with high confidence that the substances within this category will lead to the same type of effects.
For details, please refer to the category document attached to Iuclid section 13. - Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Oxygen conditions:
- aerobic
- Remarks on result:
- other: inherently biogradable based on read-across
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- Overall, esters with short carbon chains are readily biodegradable. With increasing carbon chain length, biodegradation rates decrease. Esters of branched, higher or multifunctional alcohols are not readily biodegradable but nevertheless undergo considerable biodegradation and can be considered to be inherently biodegradable. Based on the available data, ODMP is predicted to be inherently biodegradable.
Reference
Description of key information
Overall, esters with short carbon chains are readily biodegradable. With increasing carbon chain length, biodegradation rates decrease. Esters of branched, higher or multifunctional alcohols are not readily biodegradable but nevertheless undergo considerable biodegradation and can be considered to be inherently biodegradable. Based on the available data, ODMP is predicted to be inherently biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
- Type of water:
- freshwater
Additional information
Biodegradation data are available for all substances within the category, with the exception of ODMP.
3-MPA was readily biodegradable in a DOC die away study (OECD TG 301 A) and fulfilled the 10 day window criterion. MMP and BuMP were readily biodegradable in a closed bottle test (OECD TG 301 D). EHMP was readily biodegradable in a CO2 evolution test (OECD TG 301 B). The other tested substances were biodegradable to some degree, but not readily. The mono-alcohol bases esters may be considered to be inherently biodegradable, whereas lower biodegradation rates were observed especially for TMPMP, and DiPETMP.
Substance | Results |
MPA | 93% biodegradation after 10 d, readily biodegradable |
MMP | 63.4% biodegradation after 28 d, 10 day window passed, readily biodegradable |
BUMP | 62.6% biodegradation after 28 d, 10 day window passed, readily biodegradable |
EHMP | 70% biodegradation after 28 d, 10-day window failed, considered readily biodegradable |
IOMP | 55% biodegradation after 28 d, inherently biodegradable |
iC13MP | 35% biodegradation after 28 d, inherently biodegradable |
ODMP | No data; prediction: inherently biodegradable |
GDMP | 72.1% degradation after 28 d, 10-day window failed, considered readily biodegradable |
TMPMP | 9.1% biodegradation after 28 d, not biodegradable |
PETMP | 50% biodegradation after 28 d, inherently biodegradable |
Di-PETMP | 22.4% biodegradation after 28 d, inherently biodegradable |
Overall, esters with short carbon chains are readily biodegradable. With increasing carbon chain length, biodegradation rates decrease. Esters of branched, higher or multifunctional alcohols are not readily biodegradable but nevertheless undergo considerable biodegradation and can be considered to be inherently biodegradable. Based on the available data, ODMP is predicted to be inherently biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.