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EC number: 242-217-5 | CAS number: 18328-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data presented as a summary report to TSCA under the Section 8 (e) Compliance Audit Programme for Reportable Adverse Effects. A full study report is not available for evaluation of the overall study reliability but the data summary presented to TSCA is adequate to determine the acute endpoint.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Principles of method if other than guideline:
- Four rabbits exposed to 0.5 mL of undiluted test substance and assessment of dermal response at 72 hours after application
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No information
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No information
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: animals received on 16 or 23 September or 9 December 1986 and dosed on 9 or 16 October or 31 December respectively
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Room monitored over temperature range of circa 16-30°C
- Humidity (%): No information
- Air changes (per hr): No information
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: 9 October 1986 To: 7 January 1987 - Type of coverage:
- not specified
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL of undiluted test substance
- Duration of treatment / exposure:
- No data
- Observation period:
- Results presented for the 72 hour post-application observation point
- Number of animals:
- Four
- Details on study design:
- Four rabbits dosed with 0.5 ml of undiluted test material and observed subsequently for a dermal response based on elicitation of erythema and/or oedema
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: Evidence of severe tissue damage at each of the treated sites
- Basis:
- other: reaction observed at each of four treated sites
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis and eschar observed at each abraded site
- Irritant / corrosive response data:
- All four rabbits showed evidence of severe tissue damage with grade 4 erythema, necrosis and eschar apparent with oedema also present for one rabbit. The reactions were indicative of a corrosive response.
- Interpretation of results:
- Category 1 (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Evidence of corrosivity was observed under the conditions of this study.
- Executive summary:
Four rabbits were treated by application of 0.5 ml of undiluted C-1033 (N-ethylmethylallylamine) to abraded dermal sites. Dermal reactions were assessed after 72 hours. All four rabbits showed evidence of severe tissue damage with grade 4 erythema, necrosis and eschar apparent with oedema also present for one rabbit; evidence of corrosivity was observed under the conditions of this study.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8-15 October 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data presented as a summary report to TSCA under the Section 8 (e) Compliance Audit Programme for Reportable Adverse Effects. A full study report is not available for evaluation of the overall study reliability but the data summary presented to TSCA is adequate to determine the acute endpoint.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No information
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No information
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: animals received on 2 September 1986 and dosed on 8 October 1986
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Room monitored over temperature range of circa 16-30°C
- Humidity (%): No information
- Air changes (per hr): No information
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: 8 October 1986 To: 15 October 1986 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL undiluted
- Duration of treatment / exposure:
- No indication of rinsing of the treated eye
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 4, two males and two females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no details
- Time after start of exposure: no data
SCORING SYSTEM: No details provided - Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 6
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 5
- Remarks on result:
- positive indication of irritation
- Remarks:
- The cornea was completely opaque and ulcerated.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 40
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 7 d
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 7 d
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 7 d
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24 h
- Remarks on result:
- other: Unable to evaluate due to the severity of the corrosion.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 80
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24 h
- Remarks on result:
- other: Unable to evaluate due to the severity of the corrosion.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 80
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24 h
- Remarks on result:
- other: Unable to evaluate due to the severity of the corrosion.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24 h
- Remarks on result:
- other: Unable to evaluate due to the severity of the corrosion.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 80
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #4
- Time point:
- 24 h
- Remarks on result:
- other: Unable to evaluate due to the severity of the corrosion.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24 h
- Remarks on result:
- other: Unable to evaluate due to the severity of the corrosion.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 2, 3 and 4
- Time point:
- 7 d
- Remarks on result:
- not determinable
- Remarks:
- Test terminated. The animals were killed for humane reasons.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: all animals
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Remarks:
- Measurements not taken at this timepoint.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: All animals
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Measurements not taken at this timepoint.
- Irritation parameter:
- iris score
- Basis:
- animal: All animals
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Remarks:
- Measurements not taken at this timepoint.
- Irritation parameter:
- iris score
- Basis:
- animal: All animals
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Measurements not taken at this timepoint.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: All animals
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Remarks:
- Measurements not taken at this timepoint.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: All animals
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Measurements not taken at this timepoint.
- Irritant / corrosive response data:
- C-1033 was corrosive to the eye. Three of the four animals vocalized after test material administration, and at two hours exhibited corrosion of the conjunctivae (necrosis, ulceration) and the cornea was completely opaque and ulcerated.
Due to the opacity, the iris could not be evaluated. These animals were therefore killed for humane reasons. The fourth animal exhibited only slight conjunctival irritation, iritis, corneal opacity and ulceration at 24 hours. The lower outer eye lid was noted to be necrotic. Except for this necrosis and corneal stippling, this animal was free of ocular irritation by Day 7. It appears the test material did not remain in the eye long enough to produce as severe a response as noted in the other three animals. - Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Necrotic lesions indicatine a corrosive effect were observed in all treated eyes.
- Executive summary:
Four rabbits were treated by instillation of 0.1 mL of undiluted C-1033 (N-ethylmethylallylamine) to one eye. Lesions, including corneal opacity and conjunctival necrosis, developed in three of the eyes resulting in termination of the rabbits within two hours of dosing. The fourth eye also developed opacity and necrosis but the effects were slightly less severe. However the lesions, including an area of necrosis, persisted at day 7.
Reference
|
Pre-test Obs. |
Rabbit 0876 F |
Pre-test Obs. |
Rabbit 0879 M |
|||||
R |
L |
24 h |
Day 7 |
R |
L |
24 h |
Day 7 |
||
Conjunc-tiva |
Redness |
0 |
0 |
1 |
0 |
0 |
0 |
NE |
Terminated |
Chemosis |
0 |
0 |
1 |
0 |
0 |
0 |
3 |
||
Discharge |
0 |
0 |
1 |
0 |
0 |
0 |
3 |
||
Necrosis |
0 |
0 |
0 |
0 |
0 |
0 |
N |
||
Ulceration |
0 |
0 |
0 |
0 |
0 |
0 |
U |
||
Score |
0 |
0 |
6 |
0 |
0 |
0 |
-- |
||
Iris |
Iris |
0 |
0 |
1 |
0 |
0 |
0 |
NE |
|
Score |
0 |
0 |
5 |
0 |
0 |
0 |
-- |
||
Cornea |
Opacity |
0 |
0 |
2 |
0 |
0 |
0 |
4 |
|
Area |
0 |
0 |
4 |
0 |
0 |
0 |
4 |
||
Stippling |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
||
Ulceration |
0 |
0 |
2 |
0 |
0 |
0 |
4 |
||
Fluorescein |
0 |
0 |
F |
F |
0 |
0 |
F |
||
Score |
0 |
0 |
40 |
0 |
0 |
0 |
80 |
|
Pre-test Obs. |
Rabbit 0891 M |
Pre-test Obs. |
Rabbit 0888F |
|||||
R |
L |
24 h |
Day 7 |
R |
L |
24 h |
Day 7 |
||
Conjunc-tiva |
Redness |
0 |
0 |
NE |
Terminated |
0 |
0 |
NE |
Terminated |
Chemosis |
0 |
0 |
3 |
0 |
0 |
3 |
|||
Discharge |
0 |
0 |
3 |
0 |
0 |
3 |
|||
Necrosis |
0 |
0 |
N |
0 |
0 |
N |
|||
Ulceration |
0 |
0 |
0 |
0 |
0 |
0 |
|||
Score |
0 |
0 |
-- |
0 |
0 |
-- |
|||
Iris |
Iris |
0 |
0 |
NE |
0 |
0 |
NE |
||
Score |
0 |
0 |
-- |
0 |
0 |
-- |
|||
Cornea |
Opacity |
0 |
0 |
4 |
0 |
0 |
4 |
||
Area |
0 |
0 |
4 |
0 |
0 |
4 |
|||
Stippling |
0 |
0 |
0 |
0 |
0 |
0 |
|||
Ulceration |
0 |
0 |
4 |
0 |
0 |
4 |
|||
Fluorescein |
0 |
0 |
F |
0 |
0 |
F |
|||
Score |
0 |
0 |
80 |
0 |
0 |
80 |
NE not evaluated due to severity of response
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In a study of dermal irritation / corrosion, four rabbits were treated by application of 0.5 ml of undiluted N-ethylmethylallylamine to abraded dermal sites. Dermal reactions were assessed after 72 hours. All four rabbits showed evidence of severe tissue damage with grade 4 erythema, necrosis and eschar apparent with oedema also present for one rabbit; evidence of corrosivity was observed under the conditions of this study.
In a study of eye irritation, four rabbits were treated by instillation of 0.1 mL of undiluted N-ethylmethylallylamine to one eye. Lesions, including corneal opacity and conjunctival necrosis, developed in three of the eyes resulting in termination of the rabbits within two hours of dosing. The fourth eye also developed opacity and necrosis but the effects were slightly less severe. However the lesions, including an area of necrosis, persisted at day 7.
Justification for selection of skin irritation / corrosion endpoint:
Only one study available for this endpoint
Justification for selection of eye irritation endpoint:
Available data sourced from one study summary submitted in accordance with TSCA Section 8 (e) Compliance Audit Programme criteria
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the results of the available studies, N- ethylmethyl allylamine requires classification as Corrosive in Category 1 H314: Causes severe skin burns and eye damage in accordance with Regulation (EC) No. 1272/2008 (CLP Regulation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.