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EC number: 222-423-1 | CAS number: 3467-59-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: screening tests
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well performed study according to valid guidelines at that time, but without GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38 412 Part 25 (1984)
- Deviations:
- no
- Principles of method if other than guideline:
- The Zahn-Wellens test was conducted according to DIN 38 412 Part 25 (1984). This method is
corresponding with small differences to the Guideline OECD 302B.
In the Zahn-Wellens test biodegradation is determined by measuring the disappearance of DOC (DOC:
dissolved organic carbon). The method is used to test for inherent biodegradability. It specifies that the
amount of degraded DOC within the test period of normally 28 days exceeds 70 %. But, well
biodegradation in the Zahn-Wellens test does not allow an estimation of the "ready biodegradability"
according to the OECD Guidelines for Testing of Chemicals. Substances, which are degraded in the
range of 20 % to 70 % in the Zahn-Wellens-Test, are classified as primarily or slowly biodegradable.
DOC disappearance in the first three hours is caused by adsorption effects. If this occurs, the total DOC
disappearance is called "elimination", and the biodegradation is calculated by setting the value after 3 h
for 100 %. Adsorption effects may be specific for the used sludge and could lead to different results in
respect to the total elimination when the same method is performed with another source of bacteria. - GLP compliance:
- no
Test material
- Reference substance name:
- N-(2,5-dimethoxyphenyl)acetamide
- EC Number:
- 222-423-1
- EC Name:
- N-(2,5-dimethoxyphenyl)acetamide
- Cas Number:
- 3467-59-2
- Molecular formula:
- C10H13NO3
- IUPAC Name:
- N-(2,5-dimethoxyphenyl)acetamide
- Details on test material:
- purity: 99.5 %
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Details on inoculum:
- Activated sludge from the sewage treatment plant of the
Hoechst AG at Frankfurt am Main, Höchst, mixed with activated
sludge from the sewage treatment plant at Hoechst AG, site
Kelsterbach - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 479.3 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
Reference substance
- Reference substance:
- diethylene glycol
- Remarks:
- concentration: 271.6 mg DOC/L
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (DOC removal)
- Value:
- 0
- Sampling time:
- 3 h
- Parameter:
- % degradation (DOC removal)
- Value:
- 19
- Sampling time:
- 5 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 36
- Sampling time:
- 10 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 28
- Sampling time:
- 17 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 60
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- Time % degradation for diethyleneglycol
3h 8
10 67
17 94
24 100
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: evidence of inherent, primary biodegradability
- Conclusions:
- The results of testing the biodegradability in the Zahn-Wellens Test revealed that:
N-(2,5-dimethoxyphenyl)acetamide shows evidence of inherent primary biodegradability.
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