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EC number: 215-657-0 | CAS number: 1338-02-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-08-10 to 2018-09-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2019-07-15
- Type of method:
- flask method
- Specific details on test material used for the study:
- Appearance: Green, viscous paste
Storage conditions: -15 °C to 40 °C, in sealed container - Key result
- Water solubility:
- 70.9 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 300 mg/L
- Incubation duration:
- 37 d
- Temp.:
- 20 °C
- pH:
- >= 5.68 - <= 6.13
- Remarks on result:
- other: S.D: ± 6.0 mg/L
- Remarks:
- Calculated on a mean dissolved copper concentration of 8.5 ± 0.7 mg/L and a copper content of 12.0 %.
- Water solubility:
- 8.5 mg/L
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- Cu
- Loading of aqueous phase:
- 300 other: mg test item/ L
- Incubation duration:
- 37 d
- Temp.:
- 20 °C
- pH:
- >= 5.68 - <= 6.13
- Remarks on result:
- other: S.D: ± 0.7 mg/L
- Details on results:
- - Observations: A small amount of undissolved material was observed at the surface of the test solutions but mostly adhered at the sample boat. Sample boats were transferred inside the test vessels prior to start. For the method blank vessels, blank sample boats were added to the ultrapure water.
- Mean temperature: 20.1 ± 0.2 °C.
- Oxygen: no oxygen was detectable.
- pH: test item solutions: 5.3 - 6.6; method blanks: 8.5 (day 1), 7.2 – 7.9 (day 2 - 36), 6.0 and 6.5 (day 37)
- Turbidity: always < 1 NTU indicating that filtered solutions did not contain any undissolved material
- Analytical measurements:
Subtraction of method blanks is not needed. The Cu concentrations in method blanks were below LOD / LOQ or far below concentrations in actual samples.
Increase of concentrations from day 36 to day 37 were less than 15 % (validity criteria as foreseen in OECD 105 and Regulation 440/2008/EC A.6 were fulfilled).
Copper concentrations increased during the test from day 1 and 37 and even slightly from day 34 to day 35. Thus, an equilibrium could not be observed. However, further sampling was not possible. - Conclusions:
- Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of ~300 mg/L test substance in three replicates), a solubility equilibrium was not reached after day 37 of testing. The mean measured dissolved copper concentration (after filtration 0.2 µm) on day 37 at 20.0 ± 0.3 °C is 8.5 ± 0.7 mg/L.
This corresponds to a water solubility of dissolved copper naphthenate of 70.9 ± 6.0 mg/L, calculated on a copper content of 12.0 %.
Reference
ICP-MS measurement series on with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery.
Chosen isotope and gas mode |
LOD |
LOQ |
Correlation coefficient |
Sum of quality assurance samples |
Recovery of quality assurance samples [%] |
August 16, 2018; measurement of test samples and method blanks (days 1, 2, 3d) |
|||||
63Cu in helium mode |
0.007 |
0.020 |
1.0000 |
26 |
100 |
August 31, 2018; measurement of test samples and method blanks (days 15, 16, 17d) |
|||||
63Cu in high helium mode |
0.001 |
0.003 |
1.0000 |
19 |
100 |
September 13, 2018; measurement of test samples and method blanks (days 29, 30, 31) |
|||||
63Cu in high helium mode |
0.002 |
0.007 |
0.9997 |
31 |
100 |
September 20, 2018; measurement of test samples and method blanks (days 36, 37) |
|||||
63Cu in high helium mode |
0.005 |
0.014 |
0.9997 |
22 |
100 |
Recovery/validation data copper of measurement
Element Cu |
Recovery [%] |
SD [%] |
n (total) |
n (valid) |
August 16, 2018 |
||||
Quality control standard (Roth) 40 µg/L |
96.7 |
2.5 |
6 |
6 |
Recalibration standard 100 µg/L |
98.5 |
1.8 |
6 |
6 |
TMDA-70.2 (dilution factor 2), nominal value Cu: 406 µg/L – diluted 203 µg/L |
100 |
2.1 |
6 |
6 |
Quality control standard (Roth) 400 µg/L |
97.0 |
2.3 |
6 |
6 |
August 31, 2018 |
||||
Quality control standard (Roth) 40 µg/L |
101 |
2.1 |
4 |
4 |
Recalibration standard 100 µg/L |
102 |
1.0 |
4 |
4 |
TMDA-70.2 (dilution factor 2), nominal value Cu: 406 µg/L – diluted 203 µg/L |
106 |
0.9 |
4 |
4 |
Quality control standard (Roth) 400 µg/L |
101 |
0.6 |
4 |
4 |
September 13, 2018 |
||||
Quality control standard (Roth) 40 µg/L |
102 |
1.4 |
7 |
7 |
Recalibration standard 100 µg/L |
101 |
0.9 |
7 |
7 |
TMDA-70.2 (dilution factor 2), nominal value Cu: 406 µg/L – diluted 203 µg/L |
105 |
0.8 |
7 |
7 |
Quality control standard (Roth) 400 µg/L |
101 |
1.2 |
7 |
7 |
September 20, 2018 |
||||
Quality control standard (Roth) 40 µg/L |
104 |
1.7 |
5 |
5 |
Recalibration standard 100 µg/L |
102 |
0.5 |
5 |
5 |
TMDA-70.2 (dilution factor 2), nominal value Cu: 406 µg/L – diluted 203 µg/L |
108 |
1.3 |
5 |
5 |
Quality control standard (Roth) 400 µg/L |
104 |
1.1 |
5 |
5 |
Selected samples were fortified with known amounts of copper (by standard addition of commercial standard) to determine the standard recoveries of this element.
Fortification of measurement series
Sample |
Element |
Measured concentra-tion [µg/L] |
Calculated level after addition [µg/L] |
Recovery |
August 16, 2018 |
||||
Vessel 1 sample a 1d (dilution 20-fold) – 1 mL sample 4 mL 60 µg/L standard |
Cu |
14.3 |
50.9 |
49.6 / 97.5 |
Vessel 2 sample b 3d (dilution 10-fold) – 1 mL sample 4 mL 100 µg/L standard |
Cu |
78.0 |
95.6 |
93.7 / 98.0 |
August 31, 2018 |
||||
Vessel 1 sample a 15d (dilution 10-fold) – 1 mL sample 4 mL 300 µg/L standard |
Cu |
277 |
285 |
286 / 100 |
Vessel 2 sample a 16d (dilution 10-fold) – 1 mL sample 4 mL 400 µg/L standard |
Cu |
310 |
382 |
382 / 99.9 |
Vessel 3 sample a 17d (dilution 10-fold) – 1 mL sample 4 mL 500 µg/L standard |
Cu |
402 |
480 |
480 / 100 |
September 13, 2018 |
||||
Vessel 1 sample a 29d (dilution 50-fold) – 1 mL sample 4 mL 200 µg/L standard |
Cu |
135 |
187 |
187 / 99.7 |
Vessel 2 sample a 30d (dilution 50-fold) – 1 mL sample 4 mL 300 µg/L standard |
Cu |
119 |
264 |
255 / 96.6 |
Vessel 3 sample a 31d (dilution 50-fold) – 1 mL sample 4 mL 300 µg/L standard |
Cu |
126 |
265 |
264 / 99.5 |
September 20, 2018 |
||||
Vessel 3 sample a 36d (dilution 50-fold) – 1 mL sample 4 mL 200 µg/L standard |
Cu |
147 |
189 |
197 / 104 |
Vessel 2 sample a 37d (dilution 50-fold) – 1 mL sample 4 mL 300 µg/L standard |
Cu |
176 |
275 |
281 / 102 |
Calculation of water solubility according to copper content of 12%.
Sample | Cu conc. [mg/L] |
mean Cu all samples [mg/L] | SD [mg/L] |
Cu in test item [%] |
Calculated amount of test item dissolved on basis of Cu (100% Purity) [mg/L] | Mean dissolved test item [mg/L] |
SD [mg/L] | Mean all samples [mg/L] |
SD [mg/L] |
Vessel 1a day 37 | 8.79 |
8.51 |
0.71 |
12.0 |
73.3 |
70.9 |
5.9 |
70.9 |
5.9 |
Vessel 1b day 37 |
8.76 |
73.0 |
|||||||
Vessel 2a day 37 |
9.12 |
76.0 |
|||||||
Vessel 2b day 37 |
9.17 |
76.4 |
|||||||
Vessel 3a day 37 |
7.56 |
63.0 |
|||||||
Vessel 3b day 37 |
7.67 |
64.0 |
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 70.9 mg/L
- at the temperature of:
- 20 °C
Additional information
Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of ~300 mg/L test substance in three replicates), a solubility equilibrium was not reached after day 37 of testing. The mean measured dissolved copper concentration (after filtration 0.2 µm) on day 37 at 20.0 ± 0.3 °C is 8.5 ± 0.7 mg/L.
This corresponds to a water solubility of dissolved copper naphthenate of 70.9 ± 6.0 mg/L, calculated on a copper content of 12.0 %.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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