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EC number: 214-254-7 | CAS number: 1117-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to international guideline(s), GLP-compliant, performed in recognized contract research organization, no restrictions, fully adequate for assessment.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- ;2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Version / remarks:
- ;1998
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- A stock solution of 1000 mg/L was prepared in test medium. The stock solution was stirred at 30°C for 2 hours.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Source: in-house culture originating from Daphnia magna Straus collected in Langedam, Birkerød, Denmark; cultured at DHI since 1979
- Age at study initiation: < 24 h
- Feeding during test: not indicated - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 250 ± 25 mg/L as CaCO3
- Test temperature:
- 20 °C ± 0.4 °C
- pH:
- 7.7 - 7.9
- Dissolved oxygen:
- 95 - 99 % of saturation
- Nominal and measured concentrations:
- nominal concentrations: 10, 20, 50, 100, 200, 500, and 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass containers containing 25 mL of test solution
- Renewal rate of test solution (frequency/flow rate): after 24 hours
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 6
- Biomass loading rate: 5 mL medium per organism
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deinonised water
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: the test was performed in total darkness
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : numbers of immobile animals was recorded 24 hours (before and after changing the test medium) and 48 hours after the start of the study
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.0-2.5
- Range finding study: not reported - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 176 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: upper 95% confidence limit: 193 mg/L; lower limit not calculabe
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC10
- Effect conc.:
- 146 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: upper 95% confidence limit: 178 mg/L;(lower limit not calculabe
- Details on results:
- - Immobilised Daphnia: see Table 1
- Mortality of control: none - Results with reference substance (positive control):
- - Results with reference substance valid? Yes (range specified in ISO 6341 (0.6-2.1 mg/L)
- EC50/LC50: 24-hour EC50: 1.9 mg/L (95% confidence limits 1.7-2.2 mg/L). - Reported statistics and error estimates:
- The EC10 and EC50 values were calculated by Probit Analysis.
- Validity criteria fulfilled:
- yes
- Remarks:
- In the control, no Daphnia have been immobilised. The dissolved oxygen concentration at the end of the test was ≥3 mg/L (≥60% of the air saturation value at the temperature used).
Reference
Table 1: Cumulative immobilisation
Nominal concentration (mg/L) |
Cumulative numbers of immobile Daphnia |
|||
24 hours |
48 hours |
|||
total |
% |
total |
% |
|
Control |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |
0 |
50 |
0 |
0 |
0 |
0 |
100 |
0 |
0 |
0 |
0 |
200 |
9 |
45 |
17 |
85 |
500 |
20* |
100 |
20 |
100 |
1000 |
20** |
100 |
20 |
100 |
*: 90% of the test organisms were immobile after 20 min
**: 100% of the test organisms were immobile after 20 min
Description of key information
48-h EC50 > 100 mg/L for Daphnia magna (OECD TG 202, ISO 6341))
Key value for chemical safety assessment
Additional information
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