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EC number: 213-928-8 | CAS number: 1067-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The irritancy and corrosivity potential of dibutyltin di(acetate) to the skin and eye was addressed in a tiered approach. Primarily the potential for skin corrosion of the test material was assessed in the following in vitro study using a validated model:
Warren N (2010) IN VITRO SKIN CORROSION IN THE EPISKIN(TM) RECONSTITUTED HUMAN EPIDERMIS MODEL. Testing Laboratory: Harlan Laboratories Limited, Shardlow Business Park, Shardlow, Derbyshire, DE72 2GD, UK. Owner company: Organo Tin REACH Consortium, c/o ReachCentrum, Avenue E. Van Nieuwenhuyse 6, B-1160, Brussels, BELGIUM. Report No.: 3109/0028. Report date: 2010-07-19
The study was performed in compliance with GLP and using a validated model, the study was therefore assigned a reliability score of 1.
The test material was classified as Corrosive to the skin according to the OECD Guideline for the Testing of Chemicals No. 431 “In Vitro Skin Corrosion: Human Skin Model Test” (adopted 13 April 2004). The test material was classified as corrosive to the skin according to EU labelling regulations Commission Directive 2001/59/EC. The symbol “C”, the indication of danger “Corrosive” and the risk phrase R 34 “CAUSES BURNS” are therefore required. The UN packing group II is also required.
Eye:
In accordance with column 2 of REACH annex VIII, it is considered justifiable to omit the eye irritation study if the substance is classified as corrosive to the skin and provided that the registrant classifies the substance as an eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The positive results from the in vitro skin corrosion study, Warren N (2010), negates the need for further testing. The key study (Warren N, 2010), was performed to the OECD Guideline for the Testing of Chemicals No. 431 “In Vitro Skin Corrosion: Human Skin Model Test” (adopted 13 April 2004) and in compliance with GLP and is therefore considered reliable and adequate for assessment. Accordingly the study was assigned a reliability score of 1 in line with the criteria reported in Klimisch (1997).
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Skin:
The test material will be classified as corrosive to the skin according to Directive 67/548/EEC.
The symbol “C”, the indication of danger “Corrosive” and the risk phrase R 34 “CAUSES BURNS” are therefore required.According to Regulation (EC) no 1272/2008, the test substance will be classified as a Corrosive; Category 1B and so will have the hazard statement H314: causes severe skin burns and eye damage and the 'Danger' symbol.
Eye:
In accordance with column 2 of REACH annex VIII, it is considered justifiable to omit the eye irritation study if the substance is classified as corrosive to the skin and provided that the registrant classifies the substance as an eye irritant.
With this in mind, corrosive, R34; applies to both skin and eyes according to Directive 67/548/EEC.
According to Regulation (EC) no 1272/2008, the test substance will be classified as a Eye Category 1 and so will have the hazard statement H318: causes serious eye damage and the 'Danger' symbol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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