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EC number: 212-786-4 | CAS number: 869-24-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 24 mg/kg bw
- Quality of whole database:
- One high quality study is available and acceptable for the risk assessment. The most sensitive LD50 of both sexes, i.e., the LD50 of the females was used for the risk assessment.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute oral toxicity test (Coles 1990) was performed according to OECD 401 and EEC method B.1. This study is considered to be a Klimisch 1 key study. The test material has a purity of 102%. Five males and five female rat (Sprague-Dawley) were used per test group. The initial body weight ranged from 120 - 144g (males) and 126 - 159g (females) after overnight fasting. The administration was performed by gavage. Three groups, each of ten fasted animals (five males and five females), were given a single oral dose of test material preparation at dose levels of 10, 20 and 40 mg/kg bodyweight. Deaths were noted one, two and five days after dosing. One male treated with 20 mg/kg was killed in extremis on day two. Common signs of toxicity noted in the 20 and 40 mg/kg dose groups were hunched posture, piloerection, lethargy, ptosis, ataxia and loss of righting reflex. Additional signs of toxicity noted in the 40 mg/kg dose group were decreased respiratory rate, body tremors, red/brown stains around the snout, dehydration and pallor of the extremities. Surviving animals appeared normal four days after dosing. Surviving animals showed expected gain in bodyweight during the study. Abnormalities noted at necropsy of animals that died or were killed in extremis during the study were haemorrhagic or abnormally red lungs, dark liver, dark kidneys, haemorrhage of the glandular gastric epithelium and haemorrhage of the small and large intestines. The male treated with 20 mg/kg that was killed in extremis also showed an enlarged and blood filled bladder at necropsy. No abnormalities were noted at necropsy of animals killed at the end of the study.
The LD50 (males and females) was 24 mg/kg bw, the LD50 (males) was 24 mg/kg bw and the LD50 (females) was 25 mg/kg bw.
This study was performed according to international guidelines and under GLP and fulfilled the validity criteria. Therefore, this study was considered to be Klimisch 1 study.
The obtained results are considered as relevant for the risk assessment.
Justification for selection of acute toxicity – oral endpoint
only available study
Justification for classification or non-classification
The substance needs to be classified, based on criteria of Annex VI of 92-32-EC and 1272-2008-EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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