Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-828-2 | CAS number: 111-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A toxicokinetics statement can be written from the physico-chemical parameters as well as the toxicity data available on the substance.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
The physico-chemical parameters as well as the toxicity data available on the substance can estimate the absorption data according to the different routes of administration:
- inhalation route:
The low vapor pressure value permit to estimate a weak exposure by inhalation for the workers.
However, the Log Kow value is high (6.39, calculated by EPISUITE) and the water solubility is low. This lipophilic substance may be taken up by micellular solubilisation. The acute oral toxicity test did not show any significative clinical sign (LD50 > 2000 mg/kg). So the inhalation absorption could occur but the exposure by inhalation for the workers is expected to be low.
- dermal absorption:
The molecular weight of 340 triggers a possible dermal uptake. With a water solubility below 1 mg/l, dermal uptake is likely to be low as the substance must be sufficiently soluble in water to partition from the stratum corneum into the epidermis. The high Log Kow value (6.39) favours dermal absorption, but the low water solubility and the fact that Log Kow is above 6 could limit absorption across the skin. Uptake into the stratum corneum itself may be slow.
The surface tension value being below 10 mN/m, the substance will not enhance the potential dermal uptake.
A sensitization test show a dryness and edema and it was noted a potential sensitization to the skin.
The in vitro dermal irritation test do not class the substance as irritating to the skin.
These data show that the substance can penetrate the skin but moderately.
- oral absorption:
This lipophilic substance may be taken up by micellular solubilisation (Molecular weight < 500, Log Kow > 4 and low water solubility). The acute oral toxicity test did not show any significative clinical sign (LD50 > 2000 mg/kg).
So the oral absorption can occur.
No information is available regarding the distribution, metabolization and elimination of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.