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EC number: 203-828-2 | CAS number: 111-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-10-25 to 2013-03-05
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate is included in the report (date of inspection: 16 and 17 June 2011)
Test material
- Reference substance name:
- N-(2-hydroxypropyl)oleamide
- EC Number:
- 203-828-2
- EC Name:
- N-(2-hydroxypropyl)oleamide
- Cas Number:
- 111-05-7
- Molecular formula:
- C21H41NO2
- IUPAC Name:
- N-(2-hydroxypropyl)oleamide
- Reference substance name:
- N-(2-Hydroxypropyl) Oleamide
- IUPAC Name:
- N-(2-Hydroxypropyl) Oleamide
- Test material form:
- other: White waxy solid (at temperature ambiant)
- Details on test material:
- - Name of test material: N-(2-hydroxypropyl) oleamide
- Molecular formula : C21H41NO2
- Molecular weight : 339.56 g/mol
- Solubility in water: poorly
- Dry matter: 100%
- Lot/batch No.: T22221 without solvent
- pH: Not applicable
- Melting point: data not available
- Relative density: data not available
- Vapour pressure at 25°C: data not available
- Stability under test conditions: stable at room temperature
- Expiration date of the lot/batch: May 29th, 2014
- Storage condition of test material: room temperature
Constituent 1
Constituent 2
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- The inoculum was prepared from activated sludge sampled in the aeration tank treatment plant receiving predominantly domestic sewage (Montataire - (60) France). After settling, the supernatant of this activated sludge was used as inoculum with a microorganisms concentration of approximately 10.E7 active cells/L.
30 mL of inoculum were added per test flask when appropriate.
- inoculum collected on: 7 November 2012
- dry matter of activated sludge: 3.1 g/L
- Concentration of inoculum: - dry matter: 0.9 g/L
- approximately 10.E7 cells/L
- organic carbon content: 86.6 mg/L
- turbidity: 101 NTU - Duration of test (contact time):
- 0 - 28 d
Initial test substance concentration
- Initial conc.:
- 13.46 - 26.92 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: OECD 301 mineral medium
- Test temperature: between 21 and 24°C
- pH: initial pH of the mineral medium: 7.44
- pH adjusted: no
- Aeration of dilution water: No
- Suspended solids concentration: 10 mL/L of supernatant of activated sludge
- Continuous darkness: yes
- An appropriate amount of test item (40.4 mg for FE 1 and 80.8 mg for FE 2) was placed on microscope cover glass and directly introduced into the corresponding test flask with 3000 mL of test medium (as indicated in the standard NF EN ISO 10634: “Water quality: Guidance for the preparation and treatment of poorly water-soluble organic compounds for the subsequent evaluation of their biodegradability in an aqueous medium”).
TEST SYSTEM
- Number of culture flasks/concentration: one flask FE 1: 10 mg C/L and one flask FE 2: 20 mgC/L
- Method used to create aerobic conditions: aeration by the passage of carbon dioxide-free and water-free air
- Measuring equipment: titration material
- Test performed in open system: No
- Details of trap for CO2 and volatile organics if used: Ba(OH)2 trap (3 flasks of 100 mL)
- Other: Carbon analyzer SHIMADZU VSCN
SAMPLING
- Sampling frequency: every two days on average
- Sampling method: titration of one Ba(OH)2 flask
- Sample storage before analysis: No
CONTROL AND BLANK SYSTEM
- Inoculum control: yes (Aniline: FC: 20 mg C/L)
- Inoculum blank: yes
- Abiotic sterile control: yes (FA 20 mg C/L)
- Toxicity control: yes (F Inh. 20 + 20 mg C/L)
- Other: abiotic blank control
Reference substance
- Reference substance:
- aniline
- Remarks:
- Aniline, P.A. ACROS batch number: A0296028
Results and discussion
- Preliminary study:
- No preliminary study
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 86
- Sampling time:
- 28 d
- Remarks on result:
- other: average value
- Details on results:
- At 13.46 mg /L (10 mg C/L): 65.4% after 7 d
89.5% after 28 d (90.8% after 29 d and acidification)
At 26.92 mg /L (20 mg C/L): 60.1% after 7 d
82.4% after 28 d (83.2% after 29 d and acidification)
BOD5 / COD results
- Results with reference substance:
- % biodegradation: 13 d (ThCO2): 81.1% (65.4% after 7 d)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- % biodeg. FC: 65.4% after 7d and toxicity control 68.6% after 13d; difference between extrem degradation values < 20%; CO2 evolution in controls <40 mg/L (the test item is poorly soluble in water, the inorganic carbon content has not been determined)
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The pass level for ready biodegradability, 60% of ThCO2 has been reached in a 10-d window within the 28-d period of test and criteria for good evidence of “ready biodegradability” were reached in test conditions.
So, the test item N-(2-hydroxypropyl) Oleamide can be considered as readily biodegradable according to the OECD Guideline 301 for the testing of chemicals. - Executive summary:
TEST PURPOSE
Measurement, in defined conditions, of the biodegradability of an organic substance introduced in a liquid mineral medium inoculated with microbial flora from activated sludge.
TEST METHOD
OECD Guideline for the testing of chemicals 301 B: CO2Evolution Test (17 July 1992)
TEST ITEM
N-(2-hydroxypropyl) Oleamide
TEST CONCENTRATIONS
10 and 20 mg/L as organic carbon (O.C.) (nominal, initial concentrations)
REFERENCE ITEM
Aniline, 20 mg/L (O.C.)
INOCULUM
Prepared from activated sludge from a treatment plant receiving predominantly domestic sewage.
DURATION
28 days of incubation
RESULTS
- % biodegradation (%ThCO2) after 28 days of incubation:
N-(2-hydroxypropyl) Oleamide
ANILINE
10 mg C/L
20 mg C/L
20 mg C/L
89.5%
82.4%
88.0%
Mean : 86.0%
/
CONCLUSION
The pass level for ready biodegradability, 60% of ThCO2has been reached in a 10-d window within the 28-d period of test andcriteria for good evidence of “ready biodegradability” were reached in test conditions.
So, the test itemN-(2-hydroxypropyl) Oleamidecan be considered as readily biodegradable according to the OECD Guideline 301 for the testing ofchemicals.
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