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Diss Factsheets
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EC number: 202-501-1 | CAS number: 96-34-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key studies: Experimental studies conducted with the substance methyl chloroacetate:
LD50 oral (rat) = 107 mg/kg bw (no guideline was followed but the test method was similar to OECD 401).
LD50 dermal (rat) = 137 mg/kg bw (no guideline was followed but the test method was similar to OECD 402).
LD50 inhalation (rat) = 638 mg/m3 (OECD 403).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 107 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 638 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 137 mg/kg bw
Additional information
Acute oral toxicity: key study in rats which is considered the relevant species for acute oral toxicity classification. Although no guideline was followed, the test method was similar to OECD 401. This study is supported by two results from handbooks which have not been peer reviewed. One of these results was obtained in mice and the other result in rats. These results support the classification of the substance in the Acute toxicity Category 3 (oral).
Acute dermal toxicity: one study in rats and one study in rabbits. Both species are considered relevant for acute dermal toxicity classification. Therefore, the lowest effect level has been determined as the key study in order to be used for classification in the most severe category. The lowest dermal LD50 was observed in rats and supports the classification of substance in the Acute toxicity Category 2 (dermal).
Acute inhalation toxicity: key study in rats which is considered the relevant species for acute inhalation toxicity classification. The OECD guideline 403 was followed. This study is supported by one result obtained in mice and referenced in a handbook which has not been peer reviewed and one results obtained in rats which has been published in an article. These results support the classification of the substance in the Acute toxicity Category 2 (inhalation).
Justification for classification or non-classification
The oral LD50 was 107 mg/kg bw with a 95% confidence interval between 97.2 and 121 mg/kg bw. Therefore, the substance is classified as Acute Toxicity Category 3.
The dermal LD50 was 136.6 mg/kg bw with a 95% confidence interval between 121.3 and 153.7 mg/kg bw. Therefore, the substance is classified as Acute Toxicity Category 2.
The 4-h LC50 in rats was determined to be between 210 and 315 ppm (638 and 957 mg/m3). Therefore, the substance is classified as Acute Toxicity Category 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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