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EC number: 451-190-0 | CAS number: 156558-98-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Viscosity
Administrative data
Link to relevant study record(s)
- Endpoint:
- viscosity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- 3 substances available for read across
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- see the attached justification in section 13 for the full details.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Temp.:
- other: 25°C
- Parameter:
- dynamic viscosity (in mPa s)
- Value:
- 0.78
- Remarks on result:
- other: C5 FA tetraester
- Key result
- Temp.:
- other: 25°C
- Parameter:
- dynamic viscosity (in mPa s)
- Value:
- 1.51
- Remarks on result:
- other: C9 iso FA tetraester
- Key result
- Temp.:
- other: 25°C
- Parameter:
- dynamic viscosity (in mPa s)
- Value:
- 1.4
- Remarks on result:
- other: C10 testraester
- Conclusions:
- The read across for substance, CAS: 156558-98-4; EC: 451-190-0; is based upon the analogous substances to which basic form, degree of substition of functional groups is not considered to effect the proposed read across for the endpoint of viscosity. The viscosity for the substance based on the mean of the information available is deemed to be 1.23 mPa s.
- Endpoint:
- viscosity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Validated QSAR model. The substance is possibly slightly outside of the applicability domain of the model. However, this calculation is used in a weight of evidence approach, in accordance to the REACh Regulation (EC) No 1907/2006, Annex XI General rules for adaptation of the standard testing regime set out in Annexes VII to X, 1.2.
- Justification for type of information:
- Validated QSAR model.
- Principles of method if other than guideline:
- Calculation based on T.E.S.T. version v4.1, consensus method
- GLP compliance:
- no
- Type of method:
- other: QSAR
- Key result
- Temp.:
- other: 25.0°C
- Parameter:
- dynamic viscosity (in mPa s)
- Value:
- 1.4
- Endpoint:
- viscosity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Validated QSAR model. The substance is possibly outside of the applicability domain of the model. However, this calculation is used in a weight of evidence approach, in accordance to the REACh Regulation (EC) No 1907/2006, Annex XI General rules for adaptation of the standard testing regime set out in Annexes VII to X, 1.2.
- Justification for type of information:
- Validated QSAR model.
- Principles of method if other than guideline:
- Calculation based on T.E.S.T. version v4.1, consensus method
- GLP compliance:
- no
- Type of method:
- other: QSAR
- Key result
- Temp.:
- other: 25.0°C
- Parameter:
- dynamic viscosity (in mPa s)
- Value:
- 0.78
- Endpoint:
- viscosity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Validated QSAR model.
- Principles of method if other than guideline:
- Calculation based on T.E.S.T. version v4.1, consensus method
- GLP compliance:
- no
- Type of method:
- other: QSAR
- Key result
- Temp.:
- other: 25.0°C
- Parameter:
- dynamic viscosity (in mPa s)
- Value:
- 1.51
Referenceopen allclose all
Calculated result at 25 °C: log(viscosity in cP) = 1.40
Individual predictions:
Method |
Predicted value, log (cP) |
Hierarchical clustering |
N/A |
Single model |
N/A |
Group contribution |
N/A |
FDA |
1.80 |
Nearest neighbor |
1.01 |
Predictions for the test chemical and for the most similar chemicals in the external test set:
Test set chemicals |
Mean absolute error in log(cP) |
Entire set |
0.13 |
Similarity coefficient ≥ 0.5 |
0.14 |
If similar test chemicals were predicted well relative to the entire test set, one has greater confidence in a predicted value. Here 0.14 is slightly greater than 0.13. The substance is possibly slightly outside of the applicability domain.
Calculated result at 25 °C: log(viscosity in cP) = 0.78.
Individual predictions:
Method |
Predicted value, log (cP) |
Hierarchical clustering |
0.62 |
Single model |
0.62 |
Group contribution |
N/A |
FDA |
0.57 |
Nearest neighbor |
1.29 |
Predictions for the test chemical and for the most similar chemicals in the external test set:
Test set chemicals |
Mean absolute error in log(cP) |
Entire set |
0.57 |
Similarity coefficient ≥ 0.5 |
1.29 |
If similar test chemicals were predicted well relative to the entire test set, one has greater confidence in a predicted value. Here 1.29 is greater than 0.57. The substance is possibly outside of the applicability domain.
Calculated result at 25 °C: log(viscosity in cP) = 1.51.
Individual predictions:
Method |
Predicted value, log (cP) |
Hierarchical clustering |
N/A |
Single model |
N/A |
Group contribution |
N/A |
FDA |
1.73 |
Nearest neighbor |
1.29 |
Predictions for the test chemical and for the most similar chemicals in the external test set:
Test set chemicals |
Mean absolute error in log(cP) |
Entire set |
0.13 |
Similarity coefficient ≥ 0.5 |
0.12 |
If similar test chemicals were predicted well relative to the entire test set, one has greater confidence in a predicted value. Here 0.12 is lower than 0.13. The substance is likely to be in compliance with the model applicability domain.
Description of key information
The read across for substance, CAS: 156558-98-4; EC: 451-190-0; is based upon the analogous substances to which basic form, degree of substitution of functional groups is not considered to effect the proposed read across for the endpoint of viscosity. The viscosity for the substance based on the mean of the information available is deemed to be 1.23 mPa s.
Key value for chemical safety assessment
- Viscosity:
- 1.23 mPa · s (dynamic)
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.