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EC number: 231-511-9 | CAS number: 7601-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Bacterial reverse mutation test with recommended Salmonella typhimurium tester strains.
The evaluation of the toxicity was performed on the basis of the observation of any decrease in the number of revertant colonies and any thinning of the bacterial lawn using five strains of the bacteria. No noteworthy increase in the number of revertants, which could be considered to be biologically significant, was noted in any tester strains, in any experiments, with and without a metabolic activation system (S9 mix). Under the experimental conditions, Anhydrous Sodium Perchlorate did not show any mutagenic activity in the bacterial reverse mutation test with recommended Salmonella typhimurium tester strains.
Mammalian cell gene mutation test using L5178Y mouse lymphoma cells
After a preliminary toxicity test, Anhydrous Sodium Perchlorate was tested in two independent experiments, in the absence and presence of a rat liver metabolising system (S9 mix). Cytotoxicity was measured by assessment of adjusted relative total growth (Adj. RTG) and relative suspension growth (Adj. RSG) as well as cloning efficiency following the expression time (CE2). The number of mutant clones (differentiating small and large colonies) were checked after the expression of the mutant phenotype. Using a treatment volume of 100 μL/20 mL, the selected dose-levels were 156.3, 312.5, 625, 1250, 2500 and 5000 μg/mL for both mutagenicity experiments with and without the S9 mix. Following the 3-hour treatment and the 24-hour treatment without S9 mix, no noteworthy cytotoxicity was found. Similarly there was no evidence of mutagenicity, either following either the
3-hour or the 24-hour treatment. Experiments with the S9 mix revealed no noteworthy cytotoxicity in the first experiment but the second experiment showed evidence of slight toxicity at the highest dose level (5000 µg/mL), shown by a 39% decrease in Adj. RTG. However, there was no significant mutation frequency noted following the 3-hour treatment in either experiment. Under the experimental conditions, the test item did not show any mutagenic activity in the mouse lymphoma assay.
Chromosome aberrations in cultured human lymphocytes.
The test item was tested in two independent experiments, both with and without a liver metabolizing system (S9 mix), obtained from rats previously treated with Aroclor 1254. Under the experimental conditions, anhydrous sodium perchlorate did not induce chromosome aberrations in cultured human lymphocytes.
Short description of key information:
Sodium Perchlorate was investigated in a reverse mutation test on Salmonella typhimurium in accordance with OECD guideline No. 471 and EU
Method B.13/.14; in a chromosome aberration test according to OECD guideline no. 473 and EU method B.10 and in an in vitro mammalian cell
gene mutation test according to OECD no. 476 and EU method B.17.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
According to EU regulation (EC) No 1272/2008 (CLP) andEU Directive 67/584/EEC, anhydrous sodium perchlorate is not classified for mutagenicity.
Justification : Under the experimental conditions, Anhydrous Sodium Perchlorate did not show any mutagenic activity in the bacterial reverse mutation test with recommendedSalmonella typhimuriumtester strains. The test substance also failed to show any mutagenic activity in a mammalian cell gene mutation test using L5178Y mouse lymphoma cells and did not induce chromosome aberrations in cultured human lymphocytes. For all three tests the test item was tested in two independent experiments, both with and without a liver metabolizing system (S9 mix).
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