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EC number: 231-511-9 | CAS number: 7601-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 - 29 April 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Anhydrous Sodium Perchlorate
- IUPAC Name:
- Anhydrous Sodium Perchlorate
- Reference substance name:
- Sodium perchlorate
- EC Number:
- 231-511-9
- EC Name:
- Sodium perchlorate
- Cas Number:
- 7601-89-0
- Molecular formula:
- ClHO4.Na
- IUPAC Name:
- sodium perchlorate
- Details on test material:
- - Name of test material (as cited in study report): Anhydrous Sodium Perchlorate
- Physical state: white powder
- Analytical purity: 98.21%
- Purity test date: 10/01/08
- Lot/batch No.: GRL 0005/08
- Expiration date of the lot/batch: February 2010
- Storage condition of test material: room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Janvier, Le Genest-Saint-Isle, France
- Age at study initiation: 8 weeks
- Weight at study initiation: 208 ± 9g
- Fasting period before study: 18 hours prior to dosing till 4 hours after dosing
- Housing: polycarbonate cages with stainless steel lid (48x27x20cm); each cage contained autoclaved sawdust (SICSA, Alfortville, France)
- Diet: SSNIFF R/M-H pelleted maintenance diet (ad libitum except for fasting period) SSNIFF Spezialdiaten GmbH, Soest, Germany
- Water : drinking water filtered by a FG Millipore membrane (0.22µm) provided ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 30 - 70%
- Air changes (per hr): 12 cycles of filtered, non-recycled air
- Photoperiod (hrs dark / hrs light): 12 hr/12 hr (7:00-19:00)
IN-LIFE DATES: From: 01 April 2008 To: 29 April 2008
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 300 & 2000 mg/kg
- Amount of vehicle (if gavage): 10 ml/kg
- Justification for choice of vehicle: solubility
- Lot/batch no. (if required): Not reported
- Purity: purified water prepared at CIT by reverse osmosis
MAXIMUM DOSE VOLUME APPLIED: 2.2 mls
DOSAGE PREPARATION (if unusual): N/A
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: animal welfare reasons as no information on the toxic potential of the test item was available - Doses:
- 300 mg/kg and 2000 mg/kg
- No. of animals per sex per dose:
- 3 females at 300 mg/kg
6 females at 2000 mg/kg - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed frequently during the hours following administration of the test item and at least once per day
thereafter; bodyweights recorded just prior to administration of the test item on day 1 and then on days 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopic examination of main organs at necropsy - Statistics:
- No statistical analysis was performed
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no mortalities
- Clinical signs:
- other: No clinical signs were noted at 300mg/kg/day, whereas hypoactivity was noted for all animals given 2000mg/kg/day during the 2 hours following treatment.
- Gross pathology:
- Macroscopic examination of the main organs of the animals revealed no apparent abnormalities.
- Other findings:
- - Organ weights: N/A
- Histopathology: N/A
- Potential target organs: N/A
- Other observations: None
Any other information on results incl. tables
Table 1: Individual clinical signs and mortality
Dose level (mg/kg)
|
Time |
Females |
Mortality |
Clinical signs |
300 |
15 min, 1-2hr-4hr - D2 to D15 |
01-02-03 |
No |
None |
2000 (first assay) |
15 min
1 hr
2 hr
4hr- D2 to D15 |
04-05-06
04 05-06
04-05-06
04-05-06 |
No
No No
No
No |
None
Hypoactivity None
Hypoactivity
None
|
2000 (confirmatory assay) |
15 min
1hr – 2 hr
4 hr – D2 to D15 |
08 07-09
07-08-09
07-08-09 |
No No
No
No |
Hypoactivity None
Hypoactivity
None
|
min: minutes
hr: hour
D: day
Table 2: Individual and mean body weight and weekly body weight change of treated rats (g)
Dose level (mg/kg) |
Vol. mL/kg |
Sex |
Animals |
Days |
||||
1 |
(1) |
8 |
(1) |
15 |
||||
300 |
10 |
Female |
01 |
214 |
43 |
257 |
13 |
270 |
02 |
190 |
44 |
234 |
7 |
241 |
|||
03 |
211 |
52 |
263 |
9 |
272 |
|||
|
||||||||
Mean |
205 |
46 |
251 |
10 |
261 |
|||
SD |
13 |
5 |
15 |
3 |
17 |
|||
|
||||||||
2000 (first assay) |
10 |
Female |
04 |
220 |
46 |
266 |
6 |
272 |
05 |
205 |
37 |
242 |
20 |
262 |
|||
06 |
215 |
35 |
250 |
19 |
269 |
|||
|
||||||||
Mean |
213 |
39 |
253 |
15 |
268 |
|||
SD |
8 |
6 |
12 |
8 |
5 |
|||
|
||||||||
2000 (confirmatory assay) |
10 |
Female |
07 |
208 |
43 |
251 |
14 |
265 |
08 |
202 |
35 |
237 |
25 |
262 |
|||
09 |
206 |
33 |
239 |
24 |
263 |
|||
|
||||||||
Mean |
205 |
37 |
242 |
21 |
263 |
|||
SD |
3 |
5 |
8 |
6 |
2 |
|||
|
(1): bodyweight gain
SD: standard deviation
Table 3: Body weight - CIT historical data of control animals dosed (water) by oral route
Volume (mL/kg) |
Sex |
Days |
|||||
|
1 |
(1) |
8 |
(1) |
15 |
||
10 (water) |
Female |
Mean |
196 |
39 |
236 |
16 |
252 |
SD |
7 |
5 |
9 |
8 |
12 |
||
n |
30 |
30 |
30 |
30 |
30 |
(1): bodyweight gain
SD: standard deviation
n: number of animals
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Regulation (EC) No 1972/2008 on CLP
- Conclusions:
- Under the experimental conditions of this study, the oral LD50 of the test item ANHYDROUS SODIUM PERCHLORATE (batch No. lot moyen du 10/01/08 test) was higher than 2000 mg/kg in rats.
- Executive summary:
- The acute oral toxicity of the test item ANHYDROUS SODIUM PERCHLORATE (batch No. lot moyen du 10/01/08 test) was evaluated in rats according to OECD (No. 423, 17th December 2001) and EC (2004/73/EC, B.1 tris, 29th April 2004) guidelines. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations. Under the experimental conditions of this study, the oral LD0 of the test item ANHYDROUS SODIUM PERCHLORATE (batch No. lot moyen du 10/01/08 test) was higher than 2000 mg/kg in rats.
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