Registration Dossier
Registration Dossier
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EC number: 203-430-9 | CAS number: 106-75-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1968
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system. Inadequate route of exposure. Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Estimation of the acute LD50 following single i.p. injection.
- GLP compliance:
- no
Test material
- Reference substance name:
- Oxydiethylene bis(chloroformate)
- EC Number:
- 203-430-9
- EC Name:
- Oxydiethylene bis(chloroformate)
- Cas Number:
- 106-75-2
- Molecular formula:
- C6H8Cl2O5
- IUPAC Name:
- oxydiethane-2,1-diyl dichlorocarbonate
- Details on test material:
- Degree of purity not reported.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kisslegg
- Weight at study initiation:
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: water with Traganth
- Doses:
- 25, 32, 50, 64, 100, 160, 200, 1600 µl/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing was prior to the application for dose calculation. Observations were several time at the day of administration and once daily after wards except on weekends.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- none
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 56 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.04 mL/kg bw
- Mortality:
- Mortality: LD50 was about 40 µl/kg bw, equivalent to 56 mg/kg bw, based on a density of 1.39 g/ml.
25 µl/kg: 0/10
32 µl/kg: 1/10
50 µl/kg and 64 µl/kg: 8/10
100 µl/kg, 160 µl/kg, 200 µl/kg and 1600 µl/kg: 10/10 - Clinical signs:
- Dyspnea, tremor.
- Body weight:
- not determined
- Gross pathology:
- Adhesions in the abdominal cavity.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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