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EC number: 204-274-4 | CAS number: 118-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: All information on this study is derived from the review article BUA Report 85, as the complete study report is not at hand. The testing laboratory report no. is 002388
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- BUA Report 85, Ref. Hazleton 1990b
- Author:
- Beratergremium für umweltrelevante Altstoffe der Gesellschaft Deutscher Chemiker (BUA)
- Year:
- 1 992
- Bibliographic source:
- Hirzel Verlag, Stuttgart
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- Remarks:
- as only the respective review article is at hand
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetrachloro-p-benzoquinone
- EC Number:
- 204-274-4
- EC Name:
- Tetrachloro-p-benzoquinone
- Cas Number:
- 118-75-2
- Molecular formula:
- C6Cl4O2
- IUPAC Name:
- 2,3,5,6-tetrachloro-1,4-benzoquinone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: 10% (w/v) gum arabicum dispersed in water
- Details on dermal exposure:
- The test material, was administered as a paste with 96.47% (w/v) chloranil in an aqeuous dispersion of 10% (w/v) gum arabicum. This paste was applied onto the shaved, intact skin of the back and hind part of the body.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males + 5 females
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 95% CL could not be determined, as only one dose was tested.
- Mortality:
- no mortality
- Clinical signs:
- other: no intoxication symptomes, no skin lesions
- Gross pathology:
- no notable macroscopic findings
Any other information on results incl. tables
There were no premature deaths, signs of intoxication or skin lesions following 24 hours of semi-occlusive dermal exposure to the test substance at 2000 mg/kg bw. At the end of the 14-day observation period, toxicologically relevant macroscopic pathology findings were not evident.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD50: >2000 mg/kg bw
- Executive summary:
2,3,5,6-tetrachloro-1,4-benzoquinone was tested for its acute dermal toxicity similar to OECD Guideline 402. Reliability grade 4 (reliability not assignable) was assigned to the study, as all information on this study was attained only from a review article.
Over a period of 24 hours, five male and five female Sprague-Dawley rats were exposed to the test substance at the limit dose of 2000 mg/kg bw by semi-occlusive administration onto shaved, intact skin on their back and hind part. A paste with 96.47% (w/v) of the test substance in an aqeuous dispersion of 10% (w/v) gum arabic was administered. Treatment was followed by a 14-day observation period. Mortality/survival, clinical signs, skin lesions and gross necropsy findings were recorded.
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