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Diss Factsheets
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EC number: 289-339-5 | CAS number: 87741-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other:
Data source
Referenceopen allclose all
- Reference Type:
- other: EU Risk Assessment
- Title:
- European Union Risk Assessment Report 1,3-BUTADIENE, CAS No: 106-99-0, EINECS No:203-450-8
- Author:
- [ECB] European Chemicals Bureau
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- The physiological action of butadiene, butene-2 and isoprene
- Author:
- Larionov, L.F. et al.
- Year:
- 1 934
- Bibliographic source:
- Kazanskii Meditsinkii Zhurnal. 30; 440-445 (HSE translation no. 10855)
- Reference Type:
- publication
- Title:
- Studies on the inhalation of 1,3-butadiene
- Author:
- Carpenter, C.P. et al.
- Year:
- 1 944
- Bibliographic source:
- J Ind Hyg Toxicol 26; 69-78
Materials and methods
- Principles of method if other than guideline:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
- GLP compliance:
- no
Test material
- Reference substance name:
- Buta-1,3-diene
- EC Number:
- 203-450-8
- EC Name:
- Buta-1,3-diene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- buta-1,3-diene
- Details on test material:
- - Name of test material (as cited in study report): 1,3-butadiene
Constituent 1
Test animals / tissue source
- Details on test animals or tissues and environmental conditions:
- - Name of test material (as cited in study report): 1,3-butadiene
- CAS number: 106-99-0
- EINECS number: 203-450-8
Results and discussion
Any other information on results incl. tables
Only limited information is available on eye irritation.
Acute exposure to 90,000 - 140,000 ppm butadiene was reported to cause conjunctivitis in mice, and conjunctivitis and lacrimation were observed in rabbits exposed to 150,000-250,000 ppm (Larionov et al., 1934). In another study with rabbits, ophthalmoscopy revealed no signs of eye injury following exposure up to 6,700 ppm butadiene 7.5 hours/day, 6 days/week for 8 months; the same result was recorded for dogs, for which only one animal per exposure level was used (Carpenter et al., 1944).
Eye irritation has been reported in humans at very high exposure concentrations.
The gaseous nature of butadiene precludes the conduct of conventional skin and eye irritation tests in animals.
Applicant's summary and conclusion
- Executive summary:
Mice: Eye irritation at 90,000 - 140,000 ppm.
Rabbits: Eye irritation at 150,000-250,000 ppm, no eye irritation at up to 6,700 ppm daily exposure for 8 months.
Eye irritation has been reported in humans at very high exposure concentrations.
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