Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 289-339-5 | CAS number: 87741-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other:
Data source
Referenceopen allclose all
- Reference Type:
- other: EU Risk Assessment
- Title:
- European Union Risk Assessment Report 1,3-BUTADIENE, CAS No: 106-99-0, EINECS No:203-450-8
- Author:
- [ECB] European Chemicals Bureau
- Year:
- 2 002
- Reference Type:
- review article or handbook
- Title:
- Overview of reproductive and developmental toxicity studies of 1,3-butadiene in rodents.
- Author:
- Morrissey, R.E. et al.
- Year:
- 1 990
- Bibliographic source:
- Environ Health Persp. 86; 79-84.
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Principles of method if other than guideline:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Buta-1,3-diene
- EC Number:
- 203-450-8
- EC Name:
- Buta-1,3-diene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- buta-1,3-diene
- Details on test material:
- - Name of test material (as cited in study report): 1,3-butadiene
- CAS number: 106-99-0
- EINECS number: 203-450-8
Constituent 1
Test animals
- Species:
- other: rat and mouse
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- LOAEC
- Remarks:
- rat
- Effect level:
- 1 000 ppm (nominal)
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- LOAEC
- Remarks:
- mouse
- Effect level:
- 200 ppm (nominal)
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
Effect levels (fetuses)
open allclose all
- Dose descriptor:
- LOAEC
- Remarks:
- mouse
- Effect level:
- 200 ppm (nominal)
- Basis for effect level:
- other: fetotoxicity
- Dose descriptor:
- LOAEC
- Remarks:
- mouse
- Effect level:
- 200 ppm (nominal)
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
The developmental toxicity of butadiene has been investigated in mice and rats by the NTP. An overview of the studies is provided
by Morissey et al. (1990).
Groups of 31-33 pregnant Swiss CD-1 mice and 30 pregnant Sprague-Dawley rats were exposed to 0, 40, 200 or 1,000 ppm butadiene for 6 hours/day on days 6-15 of gestation (Hackett et al., 1987a,b). Mice were sacrificed on day 18 of gestation and rats on day 20. Implantation sites were recorded. Live fetuses were weighed and gross, visceral and skeletal examination made.
Maternal toxicity was elicited at the highest exposure level in rats, observed as a statistically significant, 31% reduction in bodyweight gain during gestation. Exposure to butadiene had no effect on developmental parameters at any exposure concentration. In the mouse study, a statistically significant reduction in maternal bodyweight gain during gestation was seen at 200 ppm (14% reduction) and 1,000 ppm (20% reduction). Fetal weight was statistically significantly lower at 200 ppm (16% less than control) and 1,000 ppm (22% less than control). There were no statistically significant increases in percentage resorptions or malformations per litter although
there was a slight, statistically significant increase in minor skeletal abnormalities at 200 and/or 1,000 ppm, indicative of growth retardation (supernumerary ribs, reduced sternebral ossification and misaligned, scrambled or cleft sternebrae).
These studies demonstrate that butadiene is not a developmental toxicant to the rat following inhalation exposure. However, in the mouse, butadiene appears to have a minor effect on development, with retardation in fetal bodyweight and skeletal development seen at 200 and 1,000 ppm, concentrations which also produced evidence of maternal toxicity.
In a study conducted on behalf of the IISRP, female rats were exposed to 0, 200, 1,000 or 8,000 ppm for 6 hours/day on days 6-15 of gestation and sacrificed on day 20 (Irvine, 1981). There were 40 negative controls, 24 females in each test group and 26 females in a positive control group dosed with aspirin. There was a statistically significant concentration-related reduction (14-45%) in maternal bodyweight gain at all exposure levels. There was a marginal concentration-related lowering of fetal weight and size (crown/rump length) which reached statistical significance at 8,000 ppm (mean fetal weight 6% less than control; crown/rump length
5% less than control). It was noted that the values of these parameters were low in all groups, compared with historical controls. Statistically significantly increased incidences of marked and severe forms of wavy ribs, irregular rib ossification and incomplete ossification were noted at 8,000 ppm. These effects are considered to be indicative of delayed development. There was a statistically significantly increased incidence of bipartite thoracic centra in all exposure groups. An appropriate response was seen in the positive control group. This study demonstrates that butadiene has a minor effect on fetal development at concentrations which are toxic to the dam.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.