Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 219-006-1 | CAS number: 2312-35-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7th November 1988 to 16th November 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Guideline 63-10
- Deviations:
- no
- GLP compliance:
- yes
- Dissociating properties:
- no
- pKa:
- > 12
- Remarks on result:
- other: estimated value
- Conclusions:
- Under the conditions of the test, it was determined that the test material does not exhibit a dissociation constant in the range of pKa 2 to 12. It was estimated that the test material has a pKa > 12.
- Executive summary:
In a GLP compliant dissociation constant study conducted in accordance with guideline 63-10, the dissociation constant of the test material was determined. Under the conditions of the test, the substance does not exhibit a dissociation constant in the range of pKa 2 to 12 and is estimated to have a pKa > 12.
Reference
Quantitation
Spectrophotometric method
No meaningful difference in spectral absorbance occurs at usable wavelengths. Results below 220 nm for the basic sample solutions (i.e. pH 11.8 and 12.7) should be ignored. Hydroxide ion is a strong absorber below 220 nm - the UV/Vis spectrophotometer cannot correct for the resulting high blank thus leading to anomalous results below 220 nm. No loss of concentration due to physisorption of the test substance on the glassware or degradation of the substance due to hydrolysis was observed.
Potentiometric method
No inflection attributable to the presence of the test material can be seen.
Description of key information
Dissociation constant estimated pKa > 12; study conducted in accordance with Guideline 63-10; Tang and Rose (1988)
Key value for chemical safety assessment
Additional information
In a GLP compliant dissociation constant study conducted in accordance with a standard guideline, the dissociation constant of the test material was determined. Under the conditions of the test, the substance does not exhibit a dissociation constant in the range of pKa 2 to 12 and is estimated to have a pKa > 12.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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