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Registration Dossier
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Diss Factsheets
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EC number: 412-720-6 | CAS number: 156653-67-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 12 June 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted to EU & OECD test guidance in compliance with GLP. This study is read across to the structural analogue Reaktiv-Gelb F-97494, which is considered to be structurally equivalent to the substance to be registered. Details of structure are detailed below under "illustrations"
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Details on test material:
- See below
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: > 300 deg C
- Boiling point: Not measured
- Vapour pressure: < 10E-05 hPa
- Water solubility (under test conditions): 108 g/l
- Solubility in organic solvents: Not measured.
- log Pow: < -4.9
- ready biodegradation: 8% after 28 days
- Toxicity to microorganisms: EC50 > 10000 mg/l - Radiolabelling:
- no
Study design
- Test temperature:
- No data
HPLC method
- Details on study design: HPLC method:
- The chromatographic conditions were the same for the determination of to, the establishment of the calibration graph and the measurement of the test substance.
HPLC equipment: HPLC pumpG1311A, autosampler G1313A, column oven G1316A and UV/VIS detector G1314A by Agilent
Column: Material: stainless steel, dimensions: 125 mm x 4.6 mm by Duratec (18904-02)
stationary phase: LiChrospher 100 CN 5//m
column temperature: 20°C
Mobile Phase: methanole / buffer pH 8.0
25 :75 (v/v)
isocratic elution
Flow rate: 1.0 ml/min
Injection volume: Dead time marker: 10μl
Test substance: 25μl
Calibration substances (without Direct Red): 10μl
Direct Red and test substance: 100μl
Detection wavelength: Dead time marker: 220nm
Calibration substances (without Direct Red): 220nm
Direct Red: 395nm
Test substance: 290nm
Injection amounts: Dead time marker: 2.72μg
Calibration substances: 0.71 – 7.42μg
Test substance: 3.91μg
The dead time marker was injected twice as solutions in acetonitrile/distilied water (50:50) (v/v). The calibration substances (without Direct Red) were dissolved in acetonitrile and diluted 0.1 to 1 in the mobile phase and injected as single standards twice. Direct Red and the test substance were dissolved in distilled water and diluted 0.1 to 1 in buffer pH 8 and injected as single solutions twice.
Batch equilibrium or other method
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
- Details on matrix:
- Not applicable
- Details on test conditions:
- Not applicable
- Computational methods:
- Not applicable
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- -0.24
- Remarks on result:
- other: SD 0.12, RSD 50%
Results: HPLC method
- Details on results (HPLC method):
- Tables of results listed under any other information
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- Not applicable
- Recovery of test material:
- Not applicable
- Concentration of test substance at end of adsorption equilibration period:
- Not applicable
- Concentration of test substance at end of desorption equilibration period:
- Not applicable
Any other information on results incl. tables
Log Kocof the Test Substance – 1. Measurement
Test substance |
1. Inj. tRin min |
k |
Log k |
Log Koc |
Reacktiv Gelb F-97494 |
1.99 |
0.11 |
-0.96 |
-0.16 |
Log Kocof the Test Substance – 2. Measurement
Test substance |
2. Inj. tRin min |
k |
Log k |
Log Koc |
Reaktiv Gelb F-97494 |
1.94 |
0.08 |
-1.10 |
-0.32 |
Log Kocof the Test Substance
|
Log Koc |
1. Measurement |
-0.16 |
2. Measurement |
-0.32 |
Mean |
-0.24 |
Standard deviation |
0.12 |
RSD% |
50 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test substance has been determined according to the "HPLC- method" described in guideline 67/548/EEC, appendix C.19.
It was found to be:
log Koc: -0-24
Standard deviation: 0.12
RSD: 50% - Executive summary:
The objective of this study was the determination of the adsorption coefficient Koc of the test substance according to guideline 67/548/EEC, last change dated August 06, 2001, Annex Part C:Methods for determination of ecotoxicity. C.19. estimation of the adsorption coefficient on soil and on sewage sludge using HPLC and OECD test guidelines 121, estimation of the adsorption coefficient on soil and on sewage sludge. Study performed in compliance with the Principles of Good Laboratory Practice (GLP) and reported with a GLP certificate.
The adsorption coefficient of the test substance by analogue of read across has been determined.
It was found to be:
logKoc-0-24
Standard deviation: 0.12
RSD: 50%
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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