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EC number: 412-720-6 | CAS number: 156653-67-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 24 March 1993 to 27 May 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to EU tes guidance in compliance with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EU Directive 84/449/EEC Part A7
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Details on test material:
- See below
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubility
- Medium:
- standard fat
- Solubility:
- < 0.003 mg/100 g solvent
- Temp.:
- 37 °C
- Test substance stable:
- not determined
- Details on results:
- The extinction at 425 nm of the each extract was lower than that of the calibration standard with the lowest concentration (0.15 mg/l (not com); detection limit). Thus the ratio test substance per 100 g fat was calculated from the detection limit.
For evaluation of the result one has to take into account that the spectrophotometric measurements only include organic components showing absorption at the quantification wavelength. A correction with the purity of 54 % (w/w) yields the fat solubility of Reaktiv-Gelb F-66923.
Any other information on results incl. tables
Experiment No. |
Pre-saturation |
Stirring time a 37⁰C (h) |
Mass ration test sub./fat mg/100g |
|
Stirring time (h) |
Temp (⁰C) |
|||
1 / 2 |
3 |
30 |
3 |
<0.006 |
3 / 4 |
3 |
30 |
27 |
<0.006 |
5 / 6 |
3 |
50 |
3 |
<0.006 |
7 / 8 |
3 |
50 |
27 |
<0.006 |
Applicant's summary and conclusion
- Conclusions:
- Fat solubility of Reaktiv-Gelb F-66923 in the test substance:
(Reaktiv-Gelb F-66923) < 0.003 mg/100 g fat (37 °C) - Executive summary:
The objective of this study was the determination of the fat solubility of the test substance according to EU test guidance 84/449/EEC, A.7. in compliance with GLP.
Mixtures containing circa 200 mg test substance and circa 80 g fat were stirred at 30 °C or 50 °C for 3 hours and at 37 °C (test temperature) for 3 or 27 hours.
The saturated liquid phase is separated from undissolved test substance by centrifugation at 37 °C and by filtration through a filter at 37 °C. Ca. 60 g of the liquid phase are dissolved in 100 ml n-hexane and extracted 3 times with 7 ml H2O. The extract is filled up to a volume of 25 ml, filtrated, and subjected to spectrophotometric analysis.
A pretest according to the above prescribed procedure resulted in a fat solubility less than 0.01 mg/100 g fat (not corr.).
Fat solubility of Reaktiv-Gelb F-66923 in the test substance:
(Reaktiv-Gelb F-66923) < 0.003 mg/100 g fat (37°C)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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