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EC number: 211-745-8 | CAS number: 693-21-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22.8. - 1.10.1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Acute exposure, dermal toxicity. In: Health effects test guidelines. Washington, DC: EPA, Aug 1982, EPA 560/6-82-001
- Deviations:
- yes
- Remarks:
- See Overall remarks
- Qualifier:
- according to guideline
- Guideline:
- other: Acute dermal toxicity study. LAIR Standard Operating Procedure OP-STX-30, Letterman Army Institute of Research, Presidio of San Francisco, CA. 18 May 1984
- Deviations:
- yes
- Remarks:
- See Overall remarks
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Oxydiethylene dinitrate
- EC Number:
- 211-745-8
- EC Name:
- Oxydiethylene dinitrate
- Cas Number:
- 693-21-0
- Molecular formula:
- C4H8N2O7
- IUPAC Name:
- 2-[2-(nitrooxy)ethoxy]ethyl nitrate
- Details on test material:
- - Name of test material (as cited in study report): Diethyleneglycol dinitrate (DEGDN)
- Physical state: pale yellow liquid
- Analytical purity: 96.6%
- Impurities (identity and concentrations): not identified
- Stability under test conditions: stable
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elkhorn Rabbitry, 5265 Starr Way, Watsonville, CA95076
- Age at study initiation: Young Adults
- Weight at study initiation: 2.56 - 2.72 kg
- Housing: individually in stainless steel wire mesh cages in racks equipped with automatic flushing dumptanks, no bedding was used.
- Diet (e.g. ad libitum): approximately 150 g per day of Purina Certified Rabbit Chow No. 5322 (Ralston Purina Company, St Louis, MO)
- Water (e.g. ad libitum): from central line
- Acclimation period: 10 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.8-24.4*C
- Humidity (%): 43 - 56%, except for occasional spikes to 68% during room cleaning.
- Photoperiod (hrs dark / hrs light): 12 hours of light per day
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 8x8 in. (20x20 cm)
- Type of wrap if used: gauze dressing, hypoallergenic tape and bandaging tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The exposed area was gently wiped with a piece of saline-moistened gauze.
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 3.76 - 3.99 ml - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of clinical observations and weighting:
- systemic observation: 3 times during the first 6 hours after dosing and daily for the remainder of the study
- dermal observation: the exposed area was examined and scored 1/2, 24, 48, and 72 hours after patch removal and then daily if lesions persisted.
- weighting: weekly
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality.
- Clinical signs:
- other: No systemic signs clearly attributable to the compound were observed in any of the animals. The only systemic signs observed during the study were: - slight diarrhea (2 animals) - occurred at the very end of the study in both animals and was probably not
- Gross pathology:
- No gross or microscopic findings. These minimal toxicological findings are consistent with the observation that significant quantities of test compound remained on the back after the 24-hr exposure.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A limit dose of 2 g/kg of neat diethyleneglycol dinitrate (DEGDN) was not toxic to rabbits following a 24-hr dermal exposure. DEGDN possesses a minimal potential for acute dermal toxicity.
- Executive summary:
The acute dermal toxicity of diethyleneglycol dinitrate, DEGDN, was evaluated in male and female New Zealand White rabbits. Neat DEGDN was applied topically to the clipped dorsal skin surface under a semi-occlusive wrap for 24 hours. A limit dose of 2 g/kg did not produce deaths or clinical (systemic or dermal) signs, during the two-week observation period, that could be directly attributed to administration of the DEGDN. One intriguing observation was the occurrence of curly new hair growth on 6 of the 10 rabbits in the area where DEGDN had been applied.
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