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EC number: 246-874-9 | CAS number: 25340-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Assessment of reproductive organs from 13 week inhalation study on Mixed DEB; A OECD 422 conducted using 1,4-DEB (a constituent of mixed DEB)
Additional information
Repeated inhalation exposure up to 1400 mg/m3 of DEB mixed isomers for 13 weeks did not result in any histopathological effects in reproductive organs of male or female Sprague-Dawley rats. There are no additional data available on the mixed isomers, however there is a study available on one of the isomers (1,4 -DEB) conducted by the Japanese ministry of Health.
In a combined repeat dose/reproductive/developmental toxicity screening test, Sprague-Dawley rats (12/sex/dose) were administered the supporting chemical, 1,4-diethylbenzene, via gavage at 0, 30, 150 or 750 mg/kg-bw/day. Males were dosed for 44 days, including 14 days before mating and females from 14 days before mating until Day 3 of lactation. Male and female copulation and fertility indices, pregnancy rates, and implantation sites were comparable among groups. The number of live and dead pups, the number of litters with live offspring, the mean litter size and the male-to-female ratio were comparable among the groups on lactation day 0. There were no differences in mean pup weights across groups. No differences were noted in external observations; and no remarkable findings were observed at necropsy in pups found dead prior to lactation day 4. Duration of gestation was slightly, but statistically significantly (p not stated), increased at 750 mg/kg-bw/day and there was a statistically significant (p not stated) decrease in pup survival on day 4 at 750 mg/kg-bw/day. The investigators did not consider these findings treatment-related therefore the NOAEL for systemic and reproductive toxicity is 750 mg/kg bw/day.
Effects on developmental toxicity
Description of key information
Oral Gavage Developmental toxicity study in rats using mixed isomers of DEB
Additional information
In a well-conducted prenatal developmental study in rats (20, 100, 200 mg/kg bw/d) oral gavage dosing of DEB mixed isomers did not produce any indication of developmental toxicity although there was a slight reduction noted in fetal body weight at doses (200 mg/kg bw) that also caused a decrease in maternal body weight (6%). Due to a decrease in food consumption and maternal bodyweight at 100 and 200 mg.kg bw.day the NOEL for maternal effects was listed as 20 mg/kg bw/day and the developmental NOEL was 100 mg/kg bw (due to a decrease in fetal weight attributed to decrease in maternal food consumption and bw).
Justification for classification or non-classification
In the available studies there were no effects observed on reproductive performance or on Developmental toxicity (at doses not maternally toxic). Therefore there is no justification for classifcation as a reproductive or developmental toxicant.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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