Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-874-9 | CAS number: 25340-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- no
- Remarks:
- Not specified in report.
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA (Toxic Substances Control Act): Health Effects Test Guidelines; Office of Toxlc Substances; OffIe of Pestlcldes and Toxic Substances; United States Envlromntal Protection Agency, August 1982; Acute Exposure, Demal Toxlclty.
- Deviations:
- no
- Remarks:
- Not specified in report
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Diethylbenzene
- EC Number:
- 246-874-9
- EC Name:
- Diethylbenzene
- Cas Number:
- 25340-17-4
- Molecular formula:
- C10H14
- IUPAC Name:
- diethylbenzene
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
TS: DEB Mixed isomers
IUCLID4 Test substance: as prescribed by 1.1 - 1.4
MCS 2313
Purity:Not stated
Density 0.8705 g/ml
Reference No.: NBP 3494320
Appearance: Clear colorless liquid
Purity:Not stated
Density: 0.8705 g/ml
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source: New Zealand white rabbit; Hazleton-Dutchland Laboratory Animals, Denver, PA
At start of the experiment, animals were at least 8 weeks old. The males weighed between 2.3-2.6 kg, and the females weighed between 2.6-2.7 kg.
Room temperature was 60-70 F, and relative humidity was between 30-70% during the study. Animals were observed for 14 days postdose. The light cycle was 12 hours light, 12 hours dark. Food and water were provided ad libitum.
Observations : All animals were checked for viability twice daily. Prior to assignment to study all animals were examined to ascertain suitability for study.
Husbandry: Currently acceptable practices of good animal husbandry were followed, e.g. Guide for the Care and Use of Latoratory Animals: DHEW Publication No. (NIH) 78-23 Revised 1978
Housing: Individually housed during study.
Cages: Suspended, stainless steel
Environmental Conditions: Temperature: 60-70F is considered an acceptable tmperature range for rabbits; room temperature was monitored and recorded twice daily and maintained within this range to the maximum extent possible.
Humidity: 30-70% is considered an acceptable humidity range for rabbits; room humidity was monitored and recorded daily and maintained within this range to the maximum extent possible.
Light Cycle: 12 hours light, 12 hours dark (controlled by a n automatic timer).
Food:Lab Rabbit Chow HF, (Purina #5326), ad libitum
Water: Automatic watering system, ad libitum. Municipal water supply (Elizabethtown Water Co.)
Contaminants: There were no known contaminants reasonably expected to be found in food or water which would interfere with the results of this study.
Identification: Each animal was identified with a monel eat tag, bearing a unique number, prior to testing.
Selection: Animals were randomly placed in cages upon receipt, and were placed on study as available at the time of study initiation. Any animals considered unsuitable because of poor health or outlying body weights were excluded.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- ADMINISTRATION:
Area covered: Intact skin of the dorsal area of the trunk.
Occlusion: Yes. Animals wore Elizabethan collars.
Vehicle: None
Concentration in vehicle: undiluted
Total volume applied: 5.7 ml/kg
Doses: 5000 mg/kg
Removal of test substance: Wiped free of excess test material. Additional information is not available. - Duration of exposure:
- Single dose
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5/sex/dose (total: 10 rats)
- Control animals:
- no
- Details on study design:
- Duration of study: A slngle dose was administered to each animal, followed by 14 days of observations.
Route of Administration: Dermal, to the cllpped intact skin of the dorsal area of the trunk.
Justification for Route of Administration: The study was intended to provlde information on the health hazards likely to arise from a short term accidental exposure to the test material by the dermal route.
Preparatlon of Animals: On tho day before doslng the halr of each rabbit was closely clipped from the dorsal area of the trunk with an electric cllpper, so as to expose at least 10% of the body surface area. Care was taken to avold abrading the skin. Only anlmals with intact, healthy skin were used.
Preparation of Test Material: The test material was used as received; no preparation was necessary.
Administration of Test Material: The material was applied directly on to the exposed skin of the animal and spread evenly over the entire area. Gauze was then wrapped around the animal to cover the application site. The animal was then wrapped in an impervious plastic sleeve designed to contain the test material without leakage or undue pressure. The sleeve was secured with tape and Elizabethan collars were placon all animals to prevent ingestion of the test material or disruption of the wrappings.
Following approximately24 hours of exposure, the wrappings were removed and the test site wiped free of excess test material.
Viability Checks: Twice daily
Observations of Pharmacologic and Toxicologic Signs: Approximately 1, 2. and 4 hours after dosing and daily thereafter for fourteen days.
Body Weights: Pre-test (at the time of clipping), Predose (weights used for calculation of doses) and Day 7 and Day 14
POSTMORTEM: At termination of the observation period (day 14), all animals were killed by an intravenous overdose of sodium pentobarbital and exrained grossly. All abnormalities were recorded but no tissues were saved. - Statistics:
- None
Results and discussion
- Preliminary study:
- None
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: other: Except for fissuring exhibited at a small portion of the dose site, in one animal, no severe dermal effects were seen. Decreased food consumption was exhibited by all ten animals on the day after dosing; by four animals on Day 4; and by one animal
- Gross pathology:
- Gross postmortem observations were similar to those seen in control animals in this laboratory or were considered to represent normal physiological variation.
- Other findings:
- Potential target organs: None
Sex Specific Differences: None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 > 5000 mg/kg bw.
- Executive summary:
This study was conducted to evaluate the acute dermal toxicity of MCS 2313 in rabbits following a single application of 5000 mg/kg of test material to the intact skin.
The acute dermal LD50 in rabbits is >5000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.