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EC number: 201-964-7 | CAS number: 90-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The purity of the test substance was unknown. A range of doses was only precised: the number of doses were unknown. The GLP were not mentioned but the study was performed before the GLP standard was established.
Data source
Reference
- Reference Type:
- publication
- Title:
- A comparison of the toxicity of some allyl, propenyl, and propyl compounds in the rat
- Author:
- Taylor J.M., Jenner P.M., Jones W.I.
- Year:
- 1 964
- Bibliographic source:
- Journal Toxicology and Applied Pharmacology, 6, 378-87.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: acute oral toxicity
Test material
- Reference substance name:
- Guaiacol
- EC Number:
- 201-964-7
- EC Name:
- Guaiacol
- Cas Number:
- 90-05-1
- Molecular formula:
- C7H8O2
- IUPAC Name:
- Phenol
- Details on test material:
- Guaiacol was purchased from K & K Laboratories, Inc. but its purity was unknown.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Osborne-Mendel or Sherman
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Age at study initiation: young adult
No more data
ENVIRONMENTAL CONDITIONS: no data
In-life dates: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- not detailed
- No. of animals per sex per dose:
- 5 males and 5 females at each dose.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: until the survivors had return to normal in appearance and weight
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs - Statistics:
- Litchfield and Wilcoxon method.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 725 mg/kg bw
- 95% CL:
- 302 - 1 740
- Mortality:
- Death occurred from 1 hour to 4 days after the gavage
- Clinical signs:
- other: Marked depression and comatose were noted at higher doses.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on this study, the substance is classified: Acute Tox. Category 4, H302 according to
EU GHS criteria.
- Executive summary:
In an acute oral toxicity study (Taylor, 1964), groups of young adults male/female Osborne-Mendel or Sherman rats were given a single oral dose of guaiacol (doses unspecified), and were observed until survivors had return to normal in appearance and weight.
Oral LD50 Combined = 725 mg/kg bw (with 302-1740 95% C.I.).
Guaiacol is harmful by ingestion (classified acute. Tox. Cat.4, H302) based on the LD50 of 725 mg/kg bw/day identified in both sex and according to the EU classification criteria (Annex VI of Directive 67/548/EEC and Annex I of Regulation (EC) n°1272/2208).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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