Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 432-840-2 | CAS number: 220926-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- Some temperature and humidity were outside the range. Sodium lauryl sulphate have not been applicated and the test substance concentration was not irritating (70% w/v concentration as the possible maximum soluble concentration) after topical induction.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.6 (Skin Sensitisation)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- Principles of method if other than guideline:
- Not applicable
Test material
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
Challenge
- Route:
- epicutaneous, occlusive
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 10 % w/v
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 10 % w/v. No with. + reactions: 0.0. Total no. in groups: 5.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 10 % w/v
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 10 % w/v. No with. + reactions: 0.0. Total no. in groups: 5.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 10 % w/v
- No. with + reactions:
- 2
- Total no. in group:
- 10
- Clinical observations:
- Dryness and sloughing of the epidermis in 4 animals
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 10 % w/v. No with. + reactions: 2.0. Total no. in groups: 10.0. Clinical observations: Dryness and sloughing of the epidermis in 4 animals.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 10 % w/v
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- Dryness and sloughing of the epidermis in 2 animals
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 10 % w/v. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: Dryness and sloughing of the epidermis in 2 animals.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 5 % w/v
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 5 % w/v. No with. + reactions: 0.0. Total no. in groups: 5.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 5 % w/v
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 5 % w/v. No with. + reactions: 0.0. Total no. in groups: 5.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 5 % w/v
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- Dryness and sloughing of the epidermis in 2 animals
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 5 % w/v. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: Dryness and sloughing of the epidermis in 2 animals.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 5 % w/v
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- Dryness and sloughing of the epidermis in 2 animals
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 5 % w/v. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: Dryness and sloughing of the epidermis in 2 animals.
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: Not applicable
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Not applicable
Any other information on results incl. tables
Table 7.4.1/1: Dermal reactions observed after the challenge application with E96095
Animal No. |
24 Hours |
48 Hours |
Results |
||||||
Erythema |
Oedema |
Erythema |
Oedema |
|
|||||
A |
P |
A |
P |
A |
P |
A |
P |
- |
|
1735 |
0 |
0 |
0 |
0 |
0 |
0* |
0 |
0 |
- |
1736 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
1737 |
0* |
0 |
0 |
0 |
0* |
0 |
0 |
0 |
- |
1738 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
1739 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
1740 |
1* |
0* |
0 |
0 |
0* |
0 |
0 |
0 |
± |
1741 |
0 |
0* |
0 |
0 |
0 |
0 |
0 |
0 |
- |
1742 |
0* |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
1743 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
1744 |
1* |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
± |
* Dryness and sloughing of the epidermis
A Anterior site, exposed to E96095, 10 % w/v in Alembicol D
P Posterior site, exposed to E96095, 5 % w/v in Alembicol D
Clinical signs
No sign of toxicity were observed
Bodyweight
Bodyweight increases were recorded for all guinea-pigs over the period of the study
Induction
Intradermal injections:
Necrosis were recorded at sites received Freund's Complete Adjuvant in test and control animals.
Slight irritation was seen in test animals at sites receiving E96095, 5 % w/v in Alembicol D and slight irritation was observed in control animals receiving Alembicol D.
Topical application:
No erythema was observed in test animals following topical application with E96095, 70 % w/v in Alembicol D.
No erythema was seen in the control guinea-pigs
Challenge
There were no dermal reactions seen in 8 of the 10 test animals or in any of the control animals. The remaining 2 animals gave inconclusive response.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Although ECHA is providing a lot of online material in your language, part of this page is only in English. More about ECHA’s multilingual practice.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
the-echa-website-uses-cookies
find-out-more-on how-we-use-cookies