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EC number: 406-040-9 | CAS number: 125643-61-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Assessment of Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-,C7-9-branched alkyl esters (main constituent, parent):
Test organism |
Test duration |
Effect parameter |
Effect value (mg/L) |
Nominal/ |
OECD guideline |
Vehicle |
Year of the study |
Remarks |
Brachydanio rerio |
96h |
LC50 |
>100 |
nominal |
203 |
yes |
1989 |
No effects in the range of solubility |
Oncorhynchus mykiss |
14d |
NOEC |
>=100 |
nominal |
204 |
no |
2000 |
No effects in the range of solubility |
Brachydanio rerio |
35d |
NOEC |
>=0.001 |
nominal |
210 |
yes |
2007 |
No effects in the range of solubility |
Daphnia magna |
48h |
LC50 |
>100 |
nominal |
202 |
no |
2002 |
No effects in the range of solubility |
Daphnia magna |
21d |
NOEC |
1:3.2 dilution |
loading rate 100mg/L |
211 |
no |
2000 |
Effects at the highest test concentration |
Daphnia magna |
21d |
NOEC |
>= 1mg/L |
loading rate 1mg/L |
211 |
no |
2012 |
No effects in the range of solubility |
Scenedesmus subspicatus |
72h |
LC50 NOEC |
>3 >= 3 |
nominal |
201 |
yes |
1995 |
No effects in the range of solubility |
Activated sludge | 3h | EC50 | > 100mg/L | nominal | 209 | no | 1989 |
No toxic effects of Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-,C7-9-branched alkyl esters were observed in the range of solubility. The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations. The substance is with high probability acutely and chronically not harmful to aquatic organisms.
Supporting assessment of major degradation product Metilox acid (CAS 20170-32-5)
Test organism | Test duration | Effect parameter | Effect value | Nominal/measured | OECD guideline | Vehicle | Year of the study | Remarks |
Brachydanio rerio | 96h | LC50 | 130 mg/L | nominal | 203 | yes | 1989 | A slight deposit was observed at conc. 180-320 mg/l (nominal) from the start of the test. |
Daphnia magna | 48h | LC50 | > 121 mg/L | measured | 202 | no | 2011 | |
Pseudokirchnerella subcapitata | 72h | ErC50 ErC10 | >100mg/L 95mg/L | nominal | 201 | no | 2009 | |
Activated sludge | 3h | EC50 | > 100mg/L | nominal | 209 | no | 1988 |
Acute toxicity test results are available for fish, Daphnia and algae. In an activated sludge respiration inhibition test, no adverse effects were observed. Slight toxic effects were observed in tests with fish and algae. However, these effects were caused by very high concentrations and are above the criteria for classification according to CLP.
Supporting assessment of the impurity Metilox (CAS 6386-38-5)
In a 96-h acute toxicity study to zebra-fish (Brachydanio rerio) under static conditions, the 96-h LC50 was 5.6 mg/L. The LC0, based on mortality was 3.2 mg/L.
In a 24-h acute toxicity to Daphnia magna under static conditions. The 24 -h EC50 was > 100 mg/L, the 24 -h EC0 based on immobilization was 5.8 mg/L.
In a long-term toxicity to aquatic invertebrates test with Daphnia under semi-static conditions, the NOEC based on reproduction was 0.123 mg/L based on measured concentration and 0.16 mg/L based on nominal concentraions.
In a 72 h acute toxicity study to Scenedesmus subspicatus the NOEbC and EbC50 values based on cell number were 2.3 and 0.5 mg/L, respectively.
In a 3 h acute toxicity study to sewage sludge microorganisms the IC50 value based on respiration rate was bigger than 100 mg/L after a 3 h contact time.
Supporting assessment of impurity 1 octanol (CAS 111 -87 -5)
Acute toxicity tests results are available for freshwater fish (Pimephales promelas), invertebrates (Daphnia magna) and algae (Pseudokirchnerella subcapitata). LC50 or EC50 values for the three organisms were 13.3, 20 and 14 mg/L respectively.
In waste-water treatment plant micro-organisms, octan-1-ol does not cause inhibition at the limit of water solubility. In view of the ready biodegradability, further information is not required in REACH.
A NOEC value of 1.0 mg/L (21 day reproduction) has been determined for the effects of octan-1-ol on reproduction and survival of the freshwater test organism Daphnia magna.
(ECHA disseminated data, August 04, 2015)
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