Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 421-140-2 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Two studies addressing genetic toxicity are available for RSS-4, dry substance: an Ames test (1996, rated Klimish 1) and a Mouse Micronucleus Test (1996, Klimish rated 1).
From the Ames test, it could be concluded that the test material RSS-4 did not exhibit any mutagenic activity under the conditions of the test.
The Mouse Micronucleus Test showed that
no real indication of bone marrow toxicity,as evidenced by
depression of bone marrow proliferation, was found in the
group treated with RSS-4.
Additionally, under the conditions of test, there was
no evidence of induced chromosomal or other damage leading
to micronucleus formation in polychromatic erythrocytes of
treated mice 24,48 or 72 hrs after oral administration of
RSS-4.
Short description of key information:
Both the available tests addressing genetic toxicity of the test substance (Ames test and a Mouse Micronucleus Test) had a negative outcome.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results from both the in vitro and the in vivo study, no classification (EC1272/2008) is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
