Registration Dossier
Registration Dossier
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EC number: 203-472-8 | CAS number: 107-20-0
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- American Conference of Governmental Industrial Hygienists (ACGIH)
- Author:
- Dow Chemical Co.
- Year:
- 1 986
- Bibliographic source:
- ACGIG, 120, 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Chloroacetaldehyde
- EC Number:
- 203-472-8
- EC Name:
- Chloroacetaldehyde
- Cas Number:
- 107-20-0
- Molecular formula:
- C2H3ClO
- IUPAC Name:
- 2-chloroacetaldehyde
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- other: rats, guinea pigs, rabbits, mice
Administration / exposure
- Route of administration:
- inhalation
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- 1,6 ppm; 5 ppm
- Duration of treatment / exposure:
- 6 months
- Frequency of treatment:
- 7 h/day
5 days/week
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Haematological findings:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
Effect levels
- Dose descriptor:
- NOEC
- Effect level:
- ca. 1 ppm
- Based on:
- test mat.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No adverse effects on growth, mortality, hematology, organ weights, gross and microscopic examination.
5 ppm were irritating to eyes and nose and growth of male rats was retarded slightly.
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