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EC number: 700-155-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 8 March 2011 to 29 April 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with OECD guideline and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- corn oil, peroxidised
- IUPAC Name:
- corn oil, peroxidised
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Crl:CHBB (HM) Russian
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, D-88353 Kissleg
- Age at study initiation: > 12 months old
- Weight at study initiation: 3.3kg, 2.9kg and 3.3kg
- Housing: individually in PPO cages (floor area: 2576 cm²)
- Diet: pelleted complete rabbit diet "Altromin 2123", ad libitum
- Water (e.g. ad libitum): free access to bottles with drinking water of domestic quality, which was acidified with hydrochloric acid to pH 2.5 in order to prevent microbial growth.
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature: 20°C +/- 3°C
- Humidity: preferably at least 30% and preferably no exceding 70%
- Air changes (per hr): 10 times/hour
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: from 4 April 2011 to 15 April 2011
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Only one eye was treated. The other eye remained untreated and served as a control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL
- Concentration: undiluted - Duration of treatment / exposure:
- once
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 hours
SCORING SYSTEM: according to OECD TG 405
TOOL USED TO ASSESS SCORE: UV-light / fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: (0.00, 0.00, 0.00)
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: (0.00, 0.00, 0.00)
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: (0.33, 0.33, 0.33)
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.11
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: (0.33, 0.00, 0.00)
- Irritant / corrosive response data:
- One hour after the application of the test item, the animals showed some hyperaemic conjunctival blood vessels and a swelling above normal.
24 hours after the application of the test item, some hyperaemic conjunctival blood vessels and a swelling above normal were observed in one animal. Two animals showed some hyperaemic conjunctival blood vessels.
After instillation of Fluorescein opacity of the cornea was revealed in none of the three animals.
48 hours and 72 hours after the application of the test item, the three animals were free of any signs of eye irritation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Peroxidised corn oil is not irritating to the eyes.
- Executive summary:
In a primary eye irritation study according to OECD TG 405 and GLP (Vaeth, 2011), 0.1 mLof undiluted peroxidised corn oil was instilled into the conjunctival sac of one eye of three females Russian rabbits for 24 hours. Animals then were observed for 72 hours. Irritation was scored according to the guideline.
The following mean values, based on the results from the 24-hour, 48-hour and 72-hours readings were calculated:
Animal No.
Opacity of the cornea
Iris lesion
Redness of conjunctivae
Oedema of conjunctivae
1
0.00
0.00
0.33
0.33
2
0.00
0.00
0.33
0.00
3
0.00
0.00
0.33
0.00
Based on the results, peroxidised corn oil shall not be classified as irritating to the eyes according to categories 1 or 2 of the CLP regulation.
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