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Diss Factsheets
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EC number: 938-716-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Bacterial Mutation Assay (Ames Test) With Salmonella typhimurium and Escherichia coli (screening study).
The purpose of this study was to assess the potential of the test material to induce gene mutations in vitro in bacterial strains of Salmonella typhimurium (TA98, TA100, TA1535, TA1537) and Escherichia coli WP2 uvrA (pKM101).
Study Design
A single plate incorporation test was conducted for each tester strain both in the presence and absence of rat liver S9-mix, together with appropriate vehicle and positive controls.
Results and Discussion
The data for the vehicle controls were within or close to the laboratory historical vehicle control ranges. The positive controls induced clear unequivocal increases in numbers of revertant colonies. Therefore the performance of the vehicle and positive controls were consistent with a valid assay. In the first test, the revertant counts for the vehicle controls in strain TA100 in the presence and absence of S9-mix exceeded the laboratory historical control range. Data for this strain was therefore invalidated and repeated. Only valid data have been reported. The maximum concentration analysed was limited by precipitation (observed by eye on test plates at the end of incubation) to 1500 μg per plate in the presence and absence of S9-mix.
No treatment-related increases in the numbers of revertant colonies were observed at any of the concentrations tested in this study, indicating a negative result.
CONCLUSION
The test material was not mutagenic in the bacterial mutation assay, when tested in either the presence or absence of S9-mix. The maximum concentration analysed was limited by precipitation (observed by eye on the test plates at the end of incubation) 1500 μg per plate in the presence and absence of S9-mix. 4
Short description of key information:
The test material was not mutagenic in the bacterial mutation assay, when tested in either the presence or absence of S9-mix.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The test material was not mutagenic in the bacterial mutation assay, when tested in either the presence or absence of S9-mix. The maximum concentration analysed was limited by precipitation (observed by eye on the test plates at the end of incubation) 1500 μg per plate in the presence and absence of S9-mix. 4
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