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Diss Factsheets
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EC number: 940-543-9 | CAS number: 354-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- The data source is the competent authority. Although details on test method and results are not completely described, the results are sufficient to assess acute hazard.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
- Principles of method if other than guideline:
- Test was conducted on white mice and rats at dose from 3 to 15 g/kg.
During the acute experiment dynamic monitoring of the clinical signs was carried out and the weight of animals was measured. - GLP compliance:
- not specified
- Test type:
- other: not reported
- Limit test:
- no
Test material
- Reference substance name:
- 1,1,2-trichloro-1,2-difluoroethane
- EC Number:
- 940-543-9
- Cas Number:
- 354-15-4
- Molecular formula:
- C2HCl3F2
- IUPAC Name:
- 1,1,2-trichloro-1,2-difluoroethane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): R122
- Molecular formula: CHCIF–ССI2F
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- from 3 to 15 g/kg
- No. of animals per sex per dose:
- not reported
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- 8 680 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- HCFC 122a is a low-toxic compound, experimental results were very close to the predicted LD50 value of 8680 mg/kg.
- Executive summary:
The objective of the reported study was to investigate the toxicity of HFCF 122a and HCFC 132 and to characterize their biological action in order to validate the approximate safe level of these compounds in the air of working area, ambient air, and water. In this study both a review of the available toxicological data on similar chemical compounds was made and toxicological tests on HFCF 122a and HCFC 132 were performed.
The acute toxicity levels of the HCFC 122a were both calculated and experimentally determined.
In order to obtain approximate data on the acute toxicity of the HCFC 122a and HCFC 132, the following equation, derived basing on experimental data on similar compounds, was applied:
log LD50(mmol/kg) = 1.25 – 1.54 · tb· 10-2+ 0.63 · log Pow
where:
tb= boiling point
Pow = partition coefficient octanol/water
The calculated value of LD50for HCFC 122a is reported to be 8680 mg/kg b.w.
Following the calculation of the approximated LD50, experimental studies of oral acute toxicity were conducted on white mice and rats at doses ranging from 3 to 15 g/kg.
During the acute experiment dynamic monitoring of the clinical sign was carried out and the weight of animals was measured.
Results show that HCFC 122a is a low-toxic compound, and the experimental results were very close to the predicted toxicity parameters.
Clinical signs in animals predominantly consisted of symptoms of nervous system damage. Acute poisoning within the first hours was accompanied by excitation of animals, followed by depression, motor retardation, shortness of breath, muscle atonia. Death of laboratory animals was observed within the first 1-3 days of observations. No species-sensitivity was observed. HCFC 122a and HCFC 132 did not exhibit cumulative properties.
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