Registration Dossier
Registration Dossier
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EC number: 270-984-6 | CAS number: 68512-62-9 A complex residuum from the vacuum distillation of the residuum from the atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C13 and boiling above approximately 230°C (446°F).
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: RELIABLE SUMMARY REPORT
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- IUCLID DATASET SUBSTANCE ID:68512-62-9
- Author:
- EUROPEAN CHEMICAL BUREAU
- Year:
- 2 000
- Bibliographic source:
- IUCLID DATASET SUBSTANCE ID:68512-62-9 PG 56
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- API method described in the study conducted by Elars Bioresearch Laboratories. Report No. 27–32813, API,
Washington DC, 1980. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Fuel oil, no. 6
- EC Number:
- 271-384-7
- EC Name:
- Fuel oil, no. 6
- Cas Number:
- 68553-00-4
- IUPAC Name:
- 68553-00-4
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5 consecutive days, tw o–day rest period, then 5 additional consecutive days
- Frequency of treatment:
- daily, covered for 24 hours
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
1 ml/kg/day
Basis:
nominal per unit body weight
- Remarks:
- Doses / Concentrations:
2 ml/kg/day
Basis:
nominal per unit body weight
- Remarks:
- Doses / Concentrations:
2.5 ml/kg/day
Basis:
nominal per unit body weight
- No. of animals per sex per dose:
- 4
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- ca. 1 070 mg/kg bw/day
- Based on:
- not specified
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The major systemic effect was MULTIFOCAL NECROSIS of the LIVER at ALL DOSE LEVELS. CENTRILOBULAR VACUOLAR DEGENERATION was also found. SIGNIFICANT SKIN IRRITATION was found at the TREATMENT SITES. Effects ranged from slight to severe and included acanthosis, acute inflammation, chronic inflammation, crusting, deep pyoderma, dermal congestion, dermal oedema, hyperkeratosis and epidermal necrolysis.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
