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Diss Factsheets
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EC number: 202-860-4 | CAS number: 100-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Numerous studies on the genotoxic potential of benzaldehyde are mentioned in the German MAK report on benzaldehyde (1998). In the following, only the most relevant studies for hazard assessment are presented.
Genotoxicity in vitro
The genotoxicity of benzaldehyde has been investigated in many in vitro lest systems. In Salmonella typhimurium, in mutagenicity studies with the strains TA98, TA100, TA102, TA104, TA1535, TA1537 and TA2637, and in a DNA repair lest with and without metabolic activation, no genotoxic activity could be detected. In a mutagenicity test with Escherichia coli WP2 uvrA and the mutagen 4-nitroquinoline-1-oxide, benzaldehyde from concentrations of 2120 µg/p1ate was found to have an antimutagenic effect (Watanabe et al. 1988). In Bacillus subtilis, DNA-damaging effects were observed at high concentrations only after metabolic activation. An increase in the incidence of mutants in the mause Iymphoma test occurred only in the high, cytotoxic concentration range and the finding is therefore questionable. Evidence of a weak clastogenic potential in the chromosomal aberration test and in the sister chromatid exchange test was also found only with high concentrations. Therefore there is merely evidence of weak genotoxic activity of benzaldehyde.
Genotoxicity in vivo
In the sex-linked recessive lethal test with Drosophila melanogaster, benzaldehyde administered in a concentration of 1500 ppm with the diet and injection of 2500 ppm was inactive (NTP 1990, Woodruff et al. 1985).
Endpoint Conclusion:
Justification for classification or non-classification
Based on the information on genotoxicity of benzaldehyde in vitro and in vivo, which outline, at most, only weak genotoxic activity,
no evidence is given for classification of benzaldehyde as mutagen according to Regulation (EU) 1272/2008 and Directive 67/548/EEC, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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