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EC number: 240-383-3 | CAS number: 16291-96-6 An amorphous form of carbon produced by partially burning or oxidizing wood or other organic matter.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-07-5 to 2010-08-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was performed according to EU-Method B.46 " In vitro Skin Irritation: Reconstructed human epidermis model test" (23. July 2009)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: According to Human Skin Model Test EU-Method B.46 adopted 23. July 2009
- Deviations:
- no
- Principles of method if other than guideline:
- El ensayo in vitro de irritación la piel se utiliza para determinar la irritación de la piel de los productos químicos mediante la medición de la viabilidad celular en una epidermis humana reconstruida (RHE) modelo después de aplicar la sustancia de ensayo.
El modelo RHE consta de queratinocitos epidérmicos origen humano, que han sido cultivados para formar un modelo de múltiples capas de la epidermis humana. Se identifican irritantes químicos por su capacidad para disminuir la viabilidad celular por la medición cuantitativa de la conversión enzimática de la vital MTT colorante (3 - [4,5-dimetil tiazol 2-il] 2,5-difenil-tetrazoliumbromide) a un azul formazán.
El potencial de irritación cutánea de la sustancia de ensayo se evalúa mediante la reducción de la producción de formazano a menos del 50% del control negativo. - GLP compliance:
- no
Test material
- Reference substance name:
- Charcoal
- EC Number:
- 240-383-3
- EC Name:
- Charcoal
- Cas Number:
- 16291-96-6
- IUPAC Name:
- Carbón vegetal
- Details on test material:
- Name: Charcoal (Probe 3: C-Fix = 88.7%)
Batch No.: DP07.2008/1
Appearance: Charcoal typic
CAS-No.: 16291-96-6
EINECS-No.: 240-838-3
Purity: C-Fix = 88.7%
Date of expiry: Dec. 2030
Storage conditions: Room temperature 20 ± 5°C
Constituent 1
Test animals
- Species:
- other: no aplica al ser analisis in vitro
- Strain:
- other: no aplicable
- Details on test animals or test system and environmental conditions:
- no aplicable al ser in vitro
Test system
- Type of coverage:
- other: no aplicable
- Preparation of test site:
- other: no aplicable
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 25 mg aprox.
- Duration of treatment / exposure:
- 60 min
- Observation period:
- not applicable (cell viability was determined after the end of treatment period)
- Number of animals:
- ensayo in vitro
- Details on study design:
- La prueba con modelo de piel humana se realizó con el Epi-200-SIT-Kit. Los tejidos se producen a partir de EpiDerm MatTek Corporation en Ashland, EE.UU.
El día de la entrega fue el 01. Julio 2010 por lotes: 13.657Control negativo: Fosfato de Dulbecco solución salina tamponada (DPBS) sin CaCl2 y MgCl2 Una de las placas (tres tejidos) se utilizó como control negativo, cada tejido se trató con 30 l tampón DPBS control positivo: dodecilsulfato sódico (SDS), CAS N ° 151-21-3, en solución desionizada con H2O, la concentración de 50 g / l.
Una placa (tres tejidos) se utilizó como control positivo; cada tejido se trató con 30 l de SDS-solución elemento de prueba: carbón molido compuesto de partículas < 100 micras aproximadamente 25 mg de una placa (tres tejidos) se utilizó para el tratamiento con el producto de ensayo experimental
Rendimiento: Después de la dosificación de los tejidos con el control negativo, el control positivo y producto de ensayo, se incubaron a 37 ° C durante 35 min. Después de 60 minutos un enjuague paso y seguido de dos períodos de incubación a 37 ° C durante un período total de 42 h. Después de la incubación, se realizó un ensayo MTT y la producción de formazano se midió mediante un espectrofotómetro a 570 nm.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: percentage values of formazan production in comparison to the negative control
- Basis:
- other: provided on the above section 'any other information on materials and methods incl. tables'
- Time point:
- other: 60 min
- Reversibility:
- other: no aplicable
- Remarks on result:
- other: resultado de no irritante
- Irritant / corrosive response data:
- The relative absorbance values were reduced to 89.4% after the treatment with charcoal (Probe 3: C-Fix = 88.7%). This value is above the threshold for irritation (50%). Therefore, the test item is considered not irritant. The reduction of the relative absorbance of the positive control was 7.8%.
- Other effects:
- no aplicable
Any other information on results incl. tables
Comparación de la producción de formazán: Para el producto de ensayo y el control positivo de los valores porcentuales de producción siguientes de formazano se calcularon en comparación con el control negativo:
% De producción de formazán
Designación |
Carbón vegetal |
El control positivo |
% producción Formazano (tejido 1) |
87,3% |
7,6% |
% de producción Formazán (tejido 2) |
93,1% |
8,1% |
% producción Formazano (tejido 3) |
87,7% |
7,9% |
% De la producción media de formazán |
89,4% |
7,8% |
Se puede afirmar que bajo las condiciones experimentales reportadas, el carbón no exhibió ningun potencial irritante de la piel.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- It can be stated that under the experimental conditions reported, charcoal did not exhibit any skin irritating potential.
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