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EC number: 273-761-1 | CAS number: 69012-64-2 Amorphous silicon dioxide particles from the volatilization and vaporization of furnace feed materials in the manufacture of ferrosilicon and silicon.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 19 Nov. 1991 - 23 Nov. 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Aerosil 200: approx. 99.8 % (SiO2): CAS-Name: Silica, amorphous,
fumed, cryst.-free; CAS-No.: 112945-52-5
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stirring for 20 h, then allowed to stand for 4 h before testing;
- Eluate: no, suspensions were tested
- Differential loading: yes, 1000 + 10,000 mg/L
- Controls: Synthetic medium from groundwater
- Evidence of undissolved material (e.g. precipitate, surface film, etc): The resulting suspensions at the beginning of the test were homogeneous and milky, at the end of the test in addition a layer of white, starchy flocks on the bottom of the vessels was observed.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Strain:
- Source: M.B. Ruysbroek B.V./Noordvliet 159, Maassluis
- Age at study initiation (mean and range, SD):
- Length at study initiation (length definition, mean, range and SD): 2.2 +-0.2 cm
- Weight at study initiation (mean and range, SD): 0.09 +-0.02 g
- Method of breeding:
- Feeding during test: no
ACCLIMATION
- Acclimation period: no data
- Type and amount of food: no data
- Feeding frequency: no data
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
Test conditions
- Hardness:
- 204 mg/L as CaCO3
- Test temperature:
- 24.5 - 25.3 °C
- pH:
- 7.3 - 8.2
- Dissolved oxygen:
- 7.1 - 8.2 mg/L
- Salinity:
- not applicable
- Nominal and measured concentrations:
- 1000 and 10,000 mg SiO2/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: glass beaker, 2 L, 1000 ml test suspension
- Aeration: slight aeration (no data)
- Type of flow-through (e.g. peristaltic or proportional diluter): --
- Renewal rate of test solution (frequency/flow rate): no
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- No. of vessels per vehicle control (replicates): --
- Biomass loading rate: approx. 0.9 g fish/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: prepared from groundwater by addition of several salts
- Total organic carbon: 1.7 mg/L
- Alkalinity: -- no data
- Ca/Mg ratio: 1.83
- Conductivity: --
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light, 8 h dark
- Light intensity: -- no data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): survival. swimming behaviour, colour, respiratory function,
morphological and physiological changes that were visually observable at 24, 48, 72, and 96 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10
- Justification for using less concentrations than requested by guideline: limit test, expected low toxicity
- Range finding study
- Test concentrations: --
- Results used to determine the conditions for the definitive study: -- - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LL0
- Effect conc.:
- 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks:
- 0/20 animals died
- Details on results:
- - Behavioural abnormalities: none
- Observations on body length and weight: none
- Other biological observations: no particular findings
- Mortality of control: none
- Other adverse effects control: none
- Abnormal responses: none - Results with reference substance (positive control):
- not appliicable
- Reported statistics and error estimates:
- not appliicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Aerosil 200 was not acutely toxic to Brachydanio rerio at a loading of 10,000 mg/l.
- Executive summary:
After 96 h of exposure all animals were alive and their conditiona (swimming behaviour, colour, respiratory function or any other visually observable morphological or behavioural criterion) was equal to that of the control animals.
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