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EC number: 236-691-2 | CAS number: 13465-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only, full article in chinese
Data source
Reference
- Reference Type:
- other: Publication Abstract
- Title:
- Acute toxicity and target organs assessment of subchronic exposure to hydroxylammonium nitrate in wistar rats
- Author:
- An H., Liu S-X, Gao L-H, Yang H., Cao J.
- Year:
- 2 007
- Bibliographic source:
- Journal of Toxicology
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were administered hydroxylammonium nitrate by intraperitoneal injection and observed for 14 days.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Hydroxylammonium nitrate
- EC Number:
- 236-691-2
- EC Name:
- Hydroxylammonium nitrate
- Cas Number:
- 13465-08-2
- Molecular formula:
- H3NO.HNO3
- IUPAC Name:
- hydroxylammonium nitrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- Rats were administered a range of doses of hydroxylammonium nitrate once by intraperitoneal injection.
- Doses:
- Specific range of doses not stated.
- No. of animals per sex per dose:
- Not data.
- Control animals:
- not specified
- Details on study design:
- Animals were injected with a single dose of hydroxyalmmonium hydrochloride and observed for up to 14 days.
- Statistics:
- Not data.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 139.3 mg/kg bw
- Based on:
- not specified
- 95% CL:
- ca. 132.3 - 146.7
- Mortality:
- Toxic signs (no further details stated) and morbity were observed within 14 days.
- Clinical signs:
- Not data.
- Body weight:
- No data.
- Gross pathology:
- No data.
- Other findings:
- No data.
Applicant's summary and conclusion
- Executive summary:
Rats were administered hydroxylammonium nitrate via intraperitoneal injection and observed for 14 days for toxic signs and morbity. The LD50 was 139.3 mg/kg (lower 95% confidence level 132.3 mg/kg, upper 95% confidence level 146.7 mg/kg). This study did not follow standardised guidelines and only the abstract was available, the reliability of the study is therefore considered not assignable.
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